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| 兔视网膜挫伤后视网膜神经上皮水通道蛋白4的表达 | |
| 引用本文： | 付群,师学伟,李爽,王志玉,任芳芳. 兔视网膜挫伤后视网膜神经上皮水通道蛋白4的表达[J]. 中国医药指南, 2010, 8(11): 32-35 |
| 作者姓名： | 付群 师学伟 李爽 王志玉 任芳芳 |
| 作者单位： | 1. 新乡医学院第三附属医院眼科,453000 2. 焦作市五官医院,454000 3. 新乡市中心医院,453000 4. 福建省宁德市闽东医院,355000 |
| 摘 要： | 目的观察兔实验性视网膜挫伤后视网膜神经上皮不同时段水通道蛋白4(AQP-4)的表达特点,以期进一步了解视网膜挫伤的发病机制。方法无眼疾大白兔42只,随机分组为挫伤后1h组、3h组、1d组、3d组、7d组、14d组和正常对照组;以重击法制备兔眼视网膜挫伤模型,致伤能量约为2.87J(E=mgh);于规定时间段处死受试兔,摘除眼球并取材,通过免疫组织化学法观察AQP-4在视网膜神经上皮的表达情况。结果受试各组家兔视网膜神经上皮均有AQP-4表达;与对照组相比较,AQP-4表达在视网膜挫伤后各组均明显升高(均P<0.05);伤后1h组即高于对照组(P<0.05),3h组明显升高,24h组AQP-4表达最强,3d组AQP-4表达明显下降,挫伤后7d组表达下降更为明显,14d组AQP-4表达仍高于对照组(P<0.05);各个挫伤组AQP-4表达也存在明显差异(P<0.01)。结论兔视网膜挫伤后视网膜神经上皮AQP-4表达迅速升高;推测AQP-4是挫伤后视网膜水肿病理过程的一个重要机制。 |
| 关 键 词： | 视网膜挫伤 水通道蛋白4 视网膜神经 |
Expression of Aquaporin-4 in Retinal Neurepithelium of Rabbits after Contusion |
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| FU Qun,SHI Xue-wei,LI Shuang,WANG Zhi-yu,REN Fang-fang. Expression of Aquaporin-4 in Retinal Neurepithelium of Rabbits after Contusion[J]. Guide of China Medicine, 2010, 8(11): 32-35 | |
| Authors: | FU Qun SHI Xue-wei LI Shuang WANG Zhi-yu REN Fang-fang |
| Affiliation: | FU Qun1,SHI Xue-wei2,LI Shuang3,WANG Zhi-yu4,REN Fang-fang4(1 Department of Ophthalmology,Third Affi liated Hospital of Xinxiang Medical College,Xinxiang 453003,China,2 Jiaozuo Coal Group Eye-Ear-Nose-Throat Hospital,Jiaozuuo 454000,3 Xinxiang Central Hospital,Xinxiang 453000,4 The Mindong Hospital of Ningde,Ningde 355000,China) |
| Abstract: | Objective To investigate the expression of aquaporin-4(AQP-4) in retinal neurepithelium of rabbits at different time after contusion, for the further study on the pathogenesis of retina contusion. Methods Forty-two healthy rabbits were randomized into seven groups based on different time after contusion:1h group, 3h group, 1d group, 3d group, 7d group, 14d group and the control group. To establish animal model by hitting eyeballs in the rabbits, and the hitting energy was about 2.87 J (E = mgh).Executing th... |
| Keywords: | Retinal contusion Aquaporin 4 Retina |
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