Increased prostacyclin release from perfused hearts of acutely diabetic rats |
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| Authors: | P. Rösen K. Schrör |
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| Affiliation: | (1) Abteilung für Biochemie, Diabetesforschungsinstitut an der Universität Düsseldorf, FRG;(2) Pharmakologisches Institut der Universität Köln, FRG |
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| Abstract: | Summary The release of prostacyclin and PGE2 from the isolated perfused hearts of acutely diabetic (streptozotocin 100 mg/kg) rats was studied and compared with hearts from control animals. Prostacyclin and PGE2 were measured by a differential bioassay technique. No basal release of either prostaglandin was detected. However, after addition of arachidonic acid, a dose dependent release of prostacyclin and PGE2 was noted. Prostacyclin was identified as the major prostaglandin. Release of prostacyclin and PGE2 from acutely diabetic rat hearts was increased 2–3 times compared to control hearts. No release of prostaglandin endoperoxides was observed in either group of hearts. |
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| Keywords: | Prostaglandins prostacyclin PGE2 perfused rat heart prostaglandin endoperoxides coronary flow platelet aggregation streptozotocin diabetes bioassay |
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