胎儿心脏异常钙化病因及超声特征

目的 探讨胎儿心脏异常钙化的病因及超声特征。方法 回顾性分析12胎心脏异常钙化胎儿的超声及病理学资料,分析其妊娠结局、病因及超声表现。结果 12胎中,母体抗SSA/SSB抗体（+）胎儿8胎,超声表现为心房壁、房间隔、房室瓣环等处广泛性增厚、回声增强;心肌营养不良性钙化3胎,超声表现为心室壁内局限性或广泛性高回声;特发性婴儿动脉钙化1胎,超声表现为主肺动脉和主动脉系统广泛性管壁增厚、回声增强、管腔狭窄。妊娠结局：1胎营养不良性心肌钙化病例继续妊娠中,1胎母体抗SSA/SSB（+）胎儿出生,10胎终止妊娠。结论 胎儿心脏异常钙化病因与母体抗SSA/SSB抗体（+）有关,不同病因所致超声表现有所差异。

Predisposing causes and echocardiographic findings of fetal cardiac calcifications

Objective To discuss the predisposing causes and echocardiographic findings of abnormal cardiac calcifications in fetuses. Methods The echocardiographic and pathological data of 12 fetuses with abnormal cardiac calcifications were retrospectively reviewed, and the pregnancy outcome, predisposing cause and echocardiographic features were analyzed. Results Associated maternal positive anti-SSA/SSB antibody was found in 8 fetuses. The echocardiographic findings of these 8 fetuses were extensive hyper-echogenic thickened atrial wall, interatrial septal and atrioventricular roof. Cardiac myocardium dystrophic calcification was found in 3 fetuses with focal or extensive hyper-echogenic of myocardium. Idiopathic infantile calcification with thickening and hyper-echogenic wall of main pulmonary artery and aorta with obvious stenosis of artery were observed in 1 fetus. One fetus with dystrophic myocardium calcification was continued in pregnancy, 1 maternal anti-SSA/SSB antibody (+) baby was born, and 10 fetuses were terminated. Conclusion Maternal anti SSA/SSB antibody (+) is predominantly associated with fetal cardiac calcification. Fetal abnormal cardiac calcification with different predisposing causes have different echocardiographic features.