基于历代中医文献的厚朴汤剂中厚朴常用剂量探索

目的:研究厚朴在中医汤剂中的临床常用剂量,为临床合理使用厚朴提供参考。方法:收集历代中医方剂文献中含厚朴的方剂,利用Excel 2013筛选出水煎内服的厚朴方,采用SQL Server 2008构建厚朴方数据库。采用SPSS 19.0软件统计厚朴剂量的众数、频数、均数等参数。结果:共采集到4 674首含厚朴的方剂,筛选出含有剂量的内服汤剂775首。在历代内服汤剂的厚朴方中,厚朴剂量3 g的厚朴方占总数的23.87%;3~11.2 g的厚朴方占总数的52.26%;11.3~30 g的厚朴方占总数的12.26%;30 g的厚朴方占总数的11.61%。结论:在历代中医文献中,厚朴内服汤剂的炮制主要为姜制,厚朴临床常用剂量以3.5~11 g为宜。厚朴汤剂的常用剂量在隋唐及以前相对较大,宋代以后相对较小。

Investigation of Common Dosage of Magnoliae Officinalis Cortex in Decoction Based on Ancient Literature of Traditional Chinese Medicine

Objective: To guide the clinical rational use of Magnoliae Officinalis Cortex by studying its usual oral dosage in decoction. Method: This paper collected ancient literature of traditional Chinese medicine (TCM) containing Magnoliae Officinalis Cortex,Excel 2013 was used to screen Magnoliae Officinalis Cortex formulae with water decoction and oral administration,database of Magnoliae Officinalis Cortex formulae was constructed by SQL Server 2008.SPSS 19.0 was adopted to calculate mode,frequency,mean and other parameters. Result: This study collected 4 674 formulae containing Magnoliae Officinalis Cortex from ancient literature of TCM,and 775 Magnoliae Officinalis Cortex formulae with water decoction,oral administration and containing dose were screened out.During these Magnoliae Officinalis Cortex formulae,dosage of Magnoliae Officinalis Cortex<3 g accounting for 23.87% of the total,3-11.2 g accounting for 52.26% of the total;11.3-30 g accounting for 12.26% of the total;>30 g accounting for 11.61% of the total. Conclusion: The commonly used dosage of Magnoliae Officinalis Cortex should be 3.5-11 g.In ancient literature,main processing method of Magnoliae Officinalis Cortex in decoction is ginger mix frying.The common dosage of Magnoliae Officinalis Cortex in formulae is relatively large before Song dynasty,and relatively less after Song dynasty.