Antitumor agents, 112. Emarginatine B, a novel potent cytotoxic sesquiterpene pyridine alkaloid from Maytenus emarginata |
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| Authors: | Y H Kuo C H Chen L M Kuo M L King T S Wu M Haruna K H Lee |
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| Affiliation: | Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill. |
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| Abstract: | ![]()
A new sesquiterpene pyridine alkaloid, emarginatine B [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine B showed potent cytotoxicity against human KB cells (ED50 = 0.4 micrograms/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods. |
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