原发性肺腺癌的粘液组织化学研究

目的：研究原发性肺腺癌产生粘液物质的类型、性质及分布。方法：收集２２例原发性肺腺癌进行五种粘液组化染色,ＡＢｐＨ２．５,ＡＢｐＨ１．０,ＨＩＤ－ＡＢｐＨ２．５,ＡＢｐＨ２．５－ＰＡＳ,ＰＡＳ－Ｄ。结果：２２例均见粘液细胞型粘液,２１例邮被膜型粘液（两者主要为唾液酸粘液）,１０例见到腺腔型粘液（硫酸粘液为主）。不同类型不同性质粘液可共存于同一肺腺癌中。结论：被膜型粘肺腺癌一种独立类型粘液,与粘液细胞

Study of the mucinohistochemistry in primary lung adenocarcinoma

Objective:To study the type, character and distribution of mucin in primary lung adenocarcinoma. Methods:A total of 22 cases of primary lung adenocarcinoma were studied by 5 different kinds of mucinohistochemistry, including ABpH2.5,ABpH1.0,HID ABpH2.5,ABpH2.5 PAS,and PAS D.Results:Mucino us cell type mucin (MCM) positive carcinoma cells (primarily sialomucin) were observed in all 22 cases, surface coat type mucin(SCM) positive carcinoma cells (primarily sialomucin) in 21 cases, acinar lumen type mucin(ALM)(primarily sulfomucin) in 10 cases. Different kinds of mucin can be coexisted in the same cases. Conclusions:1.SCM is a kind of mucin existed in lung adenocarcinoma, it is helpful to the diagnosis of lung adenocarcinoma. 2. The heterogenesis of pulmonary adenocarcinoma is reflected as the coexistence of different types of mucin in the same cases. 3.The acid mucin is the major mucious component of the primary lung adenocarcinoma, and detection ABpH2.5 is simple and helpful for the diagnosis of the primary lung adenocarcinoma.