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EFFECT OF DOBUTAMINE ON OXYGEN SUPPLY AND UPTAKE IN HEALTHY VOLUNTEERS
Authors:BHATT, S. B.   HUTCHINSON, R. C.   TOMLINSON, B.   OH, T. E.   MAK, M.
Affiliation:1Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong Shatin, NT, Hong Kong
2Department of Clinical Pharmacology, The Chinese University of Hong Kong Shatin, NT, Hong Kong
Abstract:
We have measured the changes in Vo2 and the Vo2; Do2 relationshipduringinfusion of dobutamine in healthy volunteers. Nine healthy,adult, non-obese, male physicians were infused with an incrementalinfusion of dobutamine starting at 2.5 µg kg–1 min–1increasing to 5.0 and then 7.5 y.g kg–1 min–1 for15 min each. Vo 2 and cardiac index were measured every fiveminutes. Vo2/(VO2 m–2) increased from a baseline of 128(SEM 6.1) ml min–1 m–2 to 159 (8.0)ml min1 m–2(P< 0.05) at 7.5 fig kg–1 min–1. The correspondingchanges for Do2l (Do2m–2) were from 643 (35) ml min–1m–2 to 1240 (142) ml min–1 m–2 (P<0.05).The coefficient of correlation for pairs of Vo2 and DO2 values,at baseline and each dobutamine infusion in individual subjects,range from 0.89 to 0.99 (mean 0.95, SD 0.03). Dobutamine haspotent calorigenic effects; demonstration of a positive correlationbetween Vo2 and Do2 after infusion of dobutamine does not necessarilyimply an underlying tissue oxygen debt.
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