| 癌基因survivin和PTEN在人类恶性肿瘤中的表达 |
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| 引用本文： | 唐丽艳,张建兵,王东林. 癌基因survivin和PTEN在人类恶性肿瘤中的表达[J]. 医学综述, 2007, 13(23): 1790-1792 |
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| 作者姓名： | 唐丽艳 张建兵 王东林 |
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| 作者单位： | 1. 南通大学医学院病理教研室,江苏,南通,226361
2. 南通市肿瘤医院病理科,江苏,南通,226361 |
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| 基金项目： | 南通市科学技术局立项资助项目 |
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| 摘 要： | Survivin是凋亡抑制蛋白家族的新成员,参与调控细胞的增殖和凋亡。研究表明,survivin在人类多种恶性肿瘤中高表达并提示预后不良。PTEN是1997年发现的具有双重特异性磷酸酶活性的抑癌基因,该基因的变异与人类多种肿瘤的发生、发展及预后有关。现就癌基因survivin和抑癌基因PTEN与人类恶性肿瘤的关系研究进展加以综述。
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| 关 键 词： | 恶性肿瘤 基因表达 Survivin PTEN |
| 文章编号： | 1006-2084(2007)23-1790-03 |
| 修稿时间： | 2007-04-04 |
Expression of Oncogene Survivin and PTEN in Human Malignant Tumors |
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| TANG Li-yan,ZHANG Jian-bing,WANG Dong-lin. Expression of Oncogene Survivin and PTEN in Human Malignant Tumors[J]. Medical Recapitulate, 2007, 13(23): 1790-1792 |
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| Authors: | TANG Li-yan ZHANG Jian-bing WANG Dong-lin |
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| Abstract: | Survivin is a newly identified member of the inhibi tor of apoptosis pr otein(IAP)family,which can regulate cell proliferation and apoptosis.Resear ches showed that high expression of survivin in most of human malignant tumor suggested poor prognosis.PTEN is a anti-oncogene with double specific phosp hatase activity found in 1997,of which the varivation is related to the genesi s,development and prognosis of many human tumor.This article reviews progres ses about relationship of oncogene survivin as well as anti-oncogene PTEN with human malignant tumor respectively. |
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| Keywords: | Survivin PTEN |
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