| 慢肝养阴胶囊对大鼠四氯化碳肝损害的保护作用 |
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| 引用本文： | 王丽新,方永奇,柯雪红,吴启端,邹衍衍,张青云.慢肝养阴胶囊对大鼠四氯化碳肝损害的保护作用[J].时珍国医国药,2001,12(9):788-789. |
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| 作者姓名： | 王丽新 方永奇 柯雪红 吴启端 邹衍衍 张青云 |
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| 作者单位： | 广州中医药大学第一附属医院, |
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| 摘 要： | 目的探讨慢肝养阴胶囊对肝脏的保护作用，以及对免疫功能的调节作用。方法造成大鼠四氯化碳(CCl4)肝损伤模型，给予慢肝养阴胶囊治疗后，测定血清谷丙转氨酶(GPT)、T淋巴细胞亚群(CD3，CD4，CD8)，及取肝组织作病理组织学检查。结果慢肝养阴胶囊能降低血清谷丙转氨酶(P＜0.01)，减轻肝组织病理组织学炎症和坏死，改善细胞免疫功能(P＜0.01)。结论慢肝养阴胶囊治疗慢性肝炎的机制之一是通过降低转氨酶、调节免疫功能而达到治疗目的。
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| 关 键 词： | 慢肝养阴胶囊 动物疾病模型 谷丙转氨酶 免疫 中药 药理 |
| 文章编号： | 1008-0805(2001)09-0788-01 |
| 修稿时间： | 2001年4月16日 |
Protective Effect of Manganyangyin Capsule on CCl4-induced Rat Liver Injury |
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| WANG Li xin,FANG Yong qi,KE Xue hong,WU Qi duan,ZOU Yan yan,ZHANG Qing yun.Protective Effect of Manganyangyin Capsule on CCl4-induced Rat Liver Injury[J].Lishizhen Medicine and Materia Medica Research,2001,12(9):788-789. |
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| Authors: | WANG Li xin FANG Yong qi KE Xue hong WU Qi duan ZOU Yan yan ZHANG Qing yun |
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| Abstract: | Objective:To explore the protective effect of Manganyangyin capsule on liver, and the regulative effect to immunity function. Methods:Make model rat CCl 4 induced liver injury. After the medication with Manganyangyin capsule, we measured serum Glutamic pyruvic transaminase (GPT), T lymphocyte subpopulation (CD 3,CD 4,CD 8) and liver's pathological histology determination. Results:Manganyangyin capsule can reduce serum GPT ( P <0.01) alleviate pathological histology inflammation and necrosis of liver, improve cell mediated immunity function ( P <0.01). Conclusion:One of the Manganyangyin capsule's therapeutic mechanism to chronic hepatitis is by reducing serum GPT and regulating immunity function. |
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| Keywords: | Manganyangyin capsule Animal disease model Rats GPT Immune |
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