| 甲硝唑缓释片处方优化研究 |
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| 引用本文： | 揭,晶,李,霞,姚,旭.甲硝唑缓释片处方优化研究[J].中国医药指南,2014(1):1-3. |
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| 作者姓名： | 揭 晶 李 霞 姚 旭 |
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| 作者单位： | 武汉生物工程学院制药工程系,湖北武汉430415 |
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| 基金项目： | 湖北省自然科学基金项目（项目编号：2012FFB05201）;2012年度湖北省高等学校青年教师深入企业行动计划项目（XD2012501） |
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| 摘 要： | 目的优化甲硝唑缓释片的处方。方法采用正交试验设计,以体外累积释放度为指标,以羟丙基甲基纤维素(HPMC)的规格、HPMC和乳糖的用量为考察因素,筛选甲硝唑缓释片的最佳处方。结果最佳处方为HPMC的规格为K4M、HPMC 20%、乳糖10%;优化后所制制剂可持续释药12 h。结论甲硝唑缓释片处方合理,具有良好的缓释效果。
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| 关 键 词： | 甲硝唑 缓释片 处方优化 累积释放度 正交试验 |
Optimization of the Formula of Metronidazole Sustained-release Tablets |
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| JIE,ling,LI Xia,YAO Xu.Optimization of the Formula of Metronidazole Sustained-release Tablets[J].Guide of China Medicine,2014(1):1-3. |
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| Authors: | JIE ling LI Xia YAO Xu |
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| Institution: | (Department of Pharmaceutical Engineering, Wuhan Institute of Bioengineeringl Wuhan 430415, China) |
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| Abstract: | Objective To optimize the formula of Metronidazol sustained-release tablets. Methods The formula of Metronidazol sustained-release tablets was optimized by orthogonal design with the accumulative release rate in vitro as index, with the specifications of HPMC, the amount of HPMC and lactose as factors. Results The optimized formula was as follows： the specification of HPMC was K4M, HMPC 20 %, lactose 10 %. The Metronidazol sustained- release tablets prepared in the optimized formulation achieved a sustained release of 12h. Conclusion The formula of the Metronidazol sustained-release tablets is reasonable and the tablets showed well release effect in vitro. |
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| Keywords: | Metronidazol Sustained-release tablets Formula optimization Accumulative release rate Orthogonal experiment |
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