| 癌基因c-myc在喉癌组织中的表达及意义 |
| |
| 引用本文： | 龙小博,胡双,曹平平,刘争,甄宏韬,崔永华. 癌基因c-myc在喉癌组织中的表达及意义[J]. 临床耳鼻咽喉头颈外科杂志, 2009, 23(24): 1127-1129 |
| |
| 作者姓名： | 龙小博 胡双 曹平平 刘争 甄宏韬 崔永华 |
| |
| 作者单位： | 华中科技大学同济医学附属同济医院耳鼻咽喉头颈外科,武汉,430030;华中科技大学同济医学附属同济医院耳鼻咽喉头颈外科,武汉,430030;华中科技大学同济医学附属同济医院耳鼻咽喉头颈外科,武汉,430030;华中科技大学同济医学附属同济医院耳鼻咽喉头颈外科,武汉,430030;华中科技大学同济医学附属同济医院耳鼻咽喉头颈外科,武汉,430030;华中科技大学同济医学附属同济医院耳鼻咽喉头颈外科,武汉,430030 |
| |
| 基金项目： | 湖北省科技厅攻关计划课题 |
| |
| 摘 要： | 目的：检测癌基因c-myc在喉癌组织中的表达并探讨其意义。方法：采用实时定量PCR和SP免疫组织化学方法分别检测喉癌组织和癌旁正常组织癌基因c-myc mRNA和蛋白的表达水平。结果：与正常喉组织比较,癌基因c-myc mRNA和蛋白水平在不同分化程度的喉癌组织中表达均明显上调（P〈0.05）,其表达水平的高低与喉癌组织的分化程度成负相关。结论：癌基因c-myc在喉癌组织中高表达,可能参与了喉癌发生发展的过程,为喉癌的基因治疗提供了新靶点。
|
| 关 键 词： | 癌基因 c-myc 喉肿瘤 |
The expression of oncogene c-myc and its role on human laryngeal cancer |
| |
| LONG Xiaobo,HU Shuang,CAO Pingping,LlU Zheng,ZHEN Hongtao,CUI Yonghua. The expression of oncogene c-myc and its role on human laryngeal cancer[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2009, 23(24): 1127-1129 |
| |
| Authors: | LONG Xiaobo HU Shuang CAO Pingping LlU Zheng ZHEN Hongtao CUI Yonghua |
| |
| Affiliation: | Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China) |
| |
| Abstract: | Objective:To detect the expression of oncogene c-myc and explore its role on human aryngeal cancer.Method:The mRNA and of oncogene c-myc levels were detected in human laryngeal cancer tissues and iaryngeal normal tissues by the means of real-time PCR and immunohistochemistry,respectively.Result:Compared with normal laryngeal tissues,the mRNA and protein levels of oncogene c-myc were both upregulated in laryngeal cancer tissues of all differentiation degree(P＜0.05).Moreover,the level of e-myc was inverse correlated with the differentiation degree in human laryngeal cancer tissues.Conclusion:The oncogene c-myc is overexpressed in human laryngeal cancer tissues,and c-myc may play an important role in carcinogenesis and progression of human laryngeal cancer tissues.It may provide a new target for gene therapy of human laryngeal cancer. |
| |
| Keywords: | c-myc oncogene c-myc laryngeal neoplasms |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
