CD44v6、E-cadherin和nm23-H1在子宫颈癌中的表达及意义

目的:探讨CD 44V 6、E-cadherin和nm 23-H 1蛋白表达与子宫颈癌的发生、发展及转移的关系。方法:采用免疫组化SP法检测50例子宫颈癌组织和10例正常子宫颈组织中CD 44v6、E-cadherin和nm 23-H 1蛋白的表达情况。结果:CD 44v6蛋白在子宫颈癌组织中的阳性率为66%,CD 44v6高表达与宫颈癌的组织学分级、淋巴结转移呈正相关(P<0.05及P<0.01)。E-cadherin和nm 23-H 1蛋白在宫颈癌组织中阳性表达率分别为62%和48%,显著低于正常宫颈组织(100.0%),P<0.05及P<0.01,但E-cadherin和nm 23-H 1阳性表达与宫颈癌的临床分期、组织学分级、间质浸润和淋巴结转移无关(P>0.05)。宫颈癌中CD 44v6表达与E-cadherin和nm 23-H 1表达呈负相关(P<0.01及P<0.05)。结论:在子宫颈癌中CD 44v6蛋白高表达和E-cadherin、nm 23-H 1蛋白低表达是判断宫颈癌的生物学行为的良好指标。

Expression and significance of CD44v6, E-cadherin and nm23-H1 in cervical carcinoma

Objective: To study the relationship between the expression of CD44v6,E-cadherin and nm23-H1 and clinical pathological factors in cervical carcinoma and the clinical significance.Methods: The expression of CD44v6,E-cadherin and nm23H1 protein were detected in 50 cases of cervical carcinoma tissue and 10 cases of normal cervical tissue with S-P immunohistochemical method.Results: In 50 cases of cervical carcinoma,the over expression of CD44v6 had a significant positive correlation with the histological staging,lymph node metastasis of cervical carcinoma(P<0.05).The positive expression of E-cadherin and nm23H1 protein in cervical carcinoma was significantly lower than that in normal cervical tissue(P<0.05,P<0.01).The expression of CD44v6 was negative relation to that of E-cadherin and nm23-H1(P<0.01,P<0.05).Conclusion: The over expression of CD44v6 and the low-expression of E-cadherin and nm23-H1 may be good indicators for predicting matastasis and the prognosis of cervical carcinoma.