nm23和血管内皮生长因子表达在非小细胞肺癌中的意义

目的 研究非小细胞肺癌(NSCLC)的预后与nm23及血管内皮生长因子(VEGF)表达间的关系。方法 对81例行手术治疗的NSCLV患者运用免疫组织化学的方法检测nm23和VEGF的表达。检测nm23、VEGF使用抗-nm23及抗-VEGF单克隆抗体。结果 在术后半年出现转移的32例NSCLC中,nm23阳性率为43％(14/32),较术后未出现转移者(71％,35/49)明显减低(P=0.004)。在32例术后半年出现转移组中,VEGF表达阳性率为75％(24/32),在49例术后未出现转移组中,VEGF表达阳性率51％(25/49)。经统计学处理,差异有显著性(P=0.031)。结论 NSCLC术后转移组nm23低表达,VEGF高表达。两指标联合应用可作为预测NSCLC预后的比较客观的指标。

Significance of nm23 and vascular endothelial growth factor expression in non-small cell lung cancer

Objective To investigate the relation between the expression of nm23, VEGF(vascular endo-thelial growth factor) and the prognosis of NSCLC(non-small cell lung cancer) .Methods Surgical specimens from 81 NSCLC were examined for nm23 and VEGF expression by immunohistochemical staining. Original anti-VEGF and anti-nm23 monoclonal antibody was used to determine VEGF and nm23 expression. Results The positive rates of nm23 in 32 patients with metastasis (43%) were significandy lower than those in 49 patients without metastasis (71%) within half years after operation (P = 0.004). Twenty-four patients (75%) were VEGF positive in 32 NSCLC patients who had metastasis and 25 patients(51%) were VEGF positive in 49 NSCLC patients who had no metastasis after operation. There were significant statistical differences between them( P = 0.031). Conclusion There are nm23 low expression and VEGF high expression in group of metastatic NSCLC. The combination of the two indexes may be a useful prognostic indicator for patients with NSCLC.