代谢综合征血清超敏C反应蛋白与冠心病关系

目的探讨代谢综合征（MS）患者血清超敏C反应蛋白（hs—CRP）含量对冠心病的预测价值。方法在珠海市湾仔区6个社区中进行慢性病筛查，选择其中符合条件且资料完整的1362人，采集空腹血液样品，检测血清hs—CRP含量及相关生化指标，比较MS、冠心病患者血清hs—CRP浓度的差异。结果1362人中，确诊MS264例（19．4％），检出高血压病患者277例（20．3％），冠心病患者164例（12．0％）；其中MS患者中合并冠心病92例（34．8％）。咀清hs—CRP受年龄、体重、吸烟、血脂及血糖水平影响，差异均有统计学意义。高血压人群、冠心病人群和MS人群的血清hs—CRP含量均高于正常人群，差异均有统计学意义。校正年龄、体质指数、空腹血糖、总胆固醇、甘油三酯等影响因素后，hs—CRP为高血压、冠心病、MS的独立危险因素。代谢指标异常数量越多。合并冠心病可能性越大，hs—CRP含量越高。结论MS患者血清hs—CRP水平是合并冠心病的独立危险因子，可预示冠心病的发生。

Relationship between serum high-sensitivity C-reactive protein and coronary heart disease with metabolic syndrome

Objective To evaluate the association between serum high-sensitivity C-reactive protein(hs-CRP) and Coronary Heart Disease with Metabolic Syndrome(MS).Methods 1326 people who accorded with admitting standardization and date completion were sampled through the chronic diseases investigation from 6 communitys in the resident site of WanZai district.Through collecting fasting blood sample ,the concentrations of h-CRP and other biochemical indicator were measured.The difference of h-CRP level between MS and Coronary Heart Disease were compared.Results During 1326 people,264(19.4%) cases were final diagnosise with MS, 277(20.3%)cases with hypertention,164(12.0%)cases with Coronary Heart Disease and,92 cases were Coronary Heart Disease with MS(34.8%).The level of hsCRP was influenced by age,body weight,smoking,blood lipid and blood glucose.The level of hs-CRP was higher in the patients with hypertention,Coronary Heart Disease and MS than normal people.the level of hs-CRP was a independent risk factor for MS or hypertention or coronary heart disease after correcting the risk factors of age,body weight,fasting blood sugar,total cholesterol and triglyceride.The more the risk factors were,the highter the level of hs-CRP was.Conclusion The level of hs-CRP is a independent risk factor for MS with coronary heart disease and can predict occurring of the coronary heart disease.