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| 糖尿病大鼠脑组织一氧化氮合酶表达的变化 | |
| 引用本文： | 贾军宏,田东华,于国平,马学毅. 糖尿病大鼠脑组织一氧化氮合酶表达的变化[J]. 军医进修学院学报, 1999, 0(1): 17-18 |
| 作者姓名： | 贾军宏 田东华 于国平 马学毅 |
| 作者单位： | 1. 解放军304医院内分泌科,北京,100037 2. 解放军总医院神经内科,北京,100853 |
| 摘 要： | 目的：探讨一氧化氮在糖尿病神经病变发病机制中的作用。方法：采用硫辛氨脱氢酶酶组织化学染色法测定糖尿病大鼠脑组织一氧化氮合酶表达的变化。结果：糖尿病成模后３个月，大脑皮层区ＮＯＳ阳性神经元明显减少，但在海马区却发现ＮＯＳ阳性细胞。结论：ＮＯＳ的改变，可能参与糖尿病中枢神经系统病变的发病过程。 |
| 关 键 词： | 糖尿病 一氧化氮合酶 中枢神经系统 |
The change of the nitric oxidesynthase expression in brain ofdiabetic rats |
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| Jia Junhong,Tiandonghua,Yuguoping,Ma Xueyi. The change of the nitric oxidesynthase expression in brain ofdiabetic rats[J]. Academic Journal of Pla Postgraduate Medical School, 1999, 0(1): 17-18 | |
| Authors: | Jia Junhong Tiandonghua Yuguoping Ma Xueyi |
| Abstract: | Objective:To explore the effects of nitric oxide on the mechanism of diabetic neuropathy. Methods:The changes of nitric oxide synthase (NOS) expression in the brain of diabetic rats were measured by the histochemiscal technique with nicotinamide adenine dinucleotide phosphate (NADPH d). Results:After inducing the model of diabetes for three months, the positive neurons of NOS in the brain contex were obviously decreased in the diabetes group than the normal control group. While the positive neuron of NOS were found in the hippocampal area of diabetes group. Conclusion:The changes of NOS expression may be a factor in the impact of diabetes on the central nervous system. |
| Keywords: | diabetes NOS CNS |
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