苦参素联合干扰素对慢性乙肝病毒定量的影响

目的 观察苦参素联合干扰素对慢性乙肝病毒定量指标的影响。方法 治疗组用苦参素联合干扰素，对照组单用干扰素，疗程均为3mon，观察治疗效果及副作用。结果 两组治疗结束后ALT和AST水平均较治疗前明显下降(P＜0．01)。HBV—DNA和HBeAg水平较治疗前明显下降(P＜0.01)。两组治疗结束后治疗组比对照组下降更明显(P＜o．01)。治疗组对白细胞和血小板下降的影响较小(P＜o．05)。结论 采用苦参素联合干扰素治疗慢性乙肝具有较好的抗病毒作用。

Effect of matrine injection combined with IFN on virul quantitative levels in the patients with chronic hepatitis B

AIM\ To observe the effect of matrine injection combine with IFN on virul quantitative levels in patients with chronic hepatitis B(CHB). METHODS\ The patients in treatment group received martine injection combined with IFN for three months and in control group received IFN alone for three months. RESULTS\ At the end of treatment, ALT and AST levels decreased significantly in both group ( P<0 01) . So do HBV DNA and HBeAg levels( P<0 01) . HBV DNA and HBeAg level in treatment group was significantly lower than those in control groups( P<0 05) . CONCLUSION\ Matrine injection combined with IFN is efficient to treat patients with CHB.