胚脑神经肽Y的免疫组织化学研究

通过免疫组织化学方法观察胚胎大鼠脑组织神经肽Ｙ的分布与含量变化。结果：大脑皮质在胚胎第２０天出现神经肽Ｙ，丘脑和下丘脑在胚胎第１４天开始出现神经肽Ｙ，并随着胎龄增加而显著增加，脑干从胚胎第１４天开始出现神经肽Ｙ，并在胚胎第１８天达到最高峰，胚胎小脑未见神经肽Ｙ阳性反应。本文对神经肽Ｙ与筛选中枢神经移植供体最佳胎龄的关系做了探讨

Distribution of Neuropeptide Y Immunoreactivity in the Rat Fetal Brain

The distribution and content alternation of NPY in the fetal rat brain was studied immunohistochemically.In the cerebral cortex, NPY was first detected at E 20 ,while in the thalamus and hypothalamus, at E 14 . The NPY density increased with the development of the thalamus and hypothalamus. In brainstem, however, NPY was detected at E 14 and reached the highest level at E 18 .The positive NPY reaction was not detected in the cerebellum of fetal rat. The relationship between NPY and selection of the best fetal age of neurotransplant was discussed.