精子介导基因转移建立转基因动物的研究进展及展望

精子介导基因转移技术制备转基因动物是在传统的转基因技术的基础上建立起来的一种新技术。由于该技术具有技术路线简单、操作方法简便、所需仪器设备少等优点,因而具有广泛的应用前景。本文主要介绍了精子介导基因转移制备转基因动物的基本原理、最新研究进展、目前存在的问题以及该技术的应用前景。

Research Progress and Prospects of Generation of Transgenic Animal by Sperm-Mediated Gene Transfer

Sperm mediated gene transfer (SMGT) is developed, a new method to generate transgenic animal based on traditional transgenic technique, because SMGT does not require special equipments, specific skills, and it merely needs simple operation. It is expected to be a potent way to generate transgenic animal. This review is a brief summary of basic principal, the most resent research progress and application perspectives of SMGT.