美托洛尔对原发性高血压患者颈动脉粥样硬化的影响

目的探讨美托洛尔对原发性高血压患者颈动脉粥样硬化的影响。方法将70例原发性高血压患者随机分为对照组（35例,常规治疗）和治疗组（35例,常规治疗＋美托洛尔25～50 mg/d）,连续治疗12周。在治疗前后测定两组患者的血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及C反应蛋白（CRP）;行颈动脉多普勒超声检查,记录颈动脉内膜-中层厚度（IMT）,计算颈动脉斑块积分和斑块检出率。结果治疗12周后,治疗组的CRP、IMT、颈动脉斑块积分数值及斑块检出率显著降低（P值〈0.05）;治疗组的CRP、IMT、颈动脉斑块积分数值及斑块检出率的降幅显著大于对照组（P值〈0.05）。结论美托洛尔可以延缓颈动脉粥样硬化的发展并消退颈动脉粥样斑块。

Effect of Metoprolol on carotid stherosclerosis in patients with essential hypertension

Objective To explore the effect of metoprolol on carotid atherosclerosis.Methods Seventy patients of essential hypertensive were randomly divided into control group ( n=35 ) and treatment group ( n=35, metoprolol 25 ～ 50 mg/d ), for twelve weeks continuously.Serum levels of total cholesterol ( TC ) triglycerides ( TG ), low-density lipoprotein holesterol ( LDL-C ), high-density lipo-protein cholesterol ( HDL-C ) and C-reactive protein were determined for both groups before and after treatment.Carotid intima-medial thickness (IMT ) was measured by ultrasound.The incidence of carotid plaque and carotid plaque scores were calculated.Results After the treatment of 12 weeks, CRP, IMT, the incidence of carotid plaque and carotid plaque scores were all significantly reduced ( P< 0.05 ).The reduction of CRP, IMT, incidence of carotid plaque and carotid plaque scores were significantly bigger in treatment group than those in control group ( P< 0.05 ).Conclusions Metoprolol can retard the progressive development of carotid atherosclerosis and the carotid artery plaque can be regressed.