血纤维蛋白原水平对皮质下血管性痴呆患者脑白质疏松的影响的临床研究

目的探讨血纤维蛋白原、同型半胱胺酸、血脂水平等因素对SVD的LA程度的影响。方法对37例在我院住院和门诊就诊的SVD病例进行血纤维蛋白原（Fib）、同型半胱氨酸（Hcy）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载脂蛋白A（Apoa）、载脂蛋白B（Apob）、甘油三酯（TG）、总胆固醇（CHOL）检测，头颅MRI检查，并收集相关的临床资料。参照Schehens学者的方法，对皮质下白质高信号影（DWMH）和脑室周围白质高信号影（PVH）程度进行半定量。比较各测定的生化指标和合并的危险因素与DWMH和PVH的半定量分数的关系。应用Pearson相关分析和简单线性回归分析的方法进行统计分析。结果Pearson相关分析显示，只有PVH与Fib的相关有统计学意义（P=0．034），是正相关关系；DWH、PVH与其他指标的相关均元统计学意义俨〉0．05）。回归分析显示，高血压、吸烟、卒中史、糖尿病、高脂血症也均不是DWH、PH的影响因素（P〉0．05）。结论m纤维蛋白原水平与SVD的PVH程度相关。

Effect of plasma fibrinogen level on leukoaraiosis in patients with subcortical vascular dementia

ObjeetiTe To investigate the effect of levels of fibrinogen, plasma homocysteine, and blood lipids on the degree of leukoaraiosis in patients with subcortical vascular dementia （SVD）. btelhods Blood levels of fibrinogen, homocysteine, high-density lipoprotein, low-density lipoprotein, apolipoprotein A, apolipoprotein B, triglyceride, and total cholesterol were measured in 37 hospitalized or clinic patients with SVD. Head was detected by magnetic resonance. According to Scheltens＇ s apporach, deep white matter hyperintense signals （DWMH） and periventricular hyperintensity （PVH） were determined semiquantitatively. All the collected biochemical indicators and risk factors were compared with the semiquantitative scores of DWMH and PVH. The clinical datas were analyzed by Pearson correlation analysis and single linear regression analysis, Results Pearson correlation analysis showed only plasma Fib level was positively related to the degree of PVH in SVD （P=0.034）, and this relation didn＇ t exist between leukoaraiosis （DWMH and PVH） and other biochemical indicators （P〉O.05）. Single linear regression analysis revealed leukoaraiosis （DWMH and PVH） was not related with hypertension, smoking, stroke, diabetes, and hyperlipoidemia （/9〉0.05）. Cotcltufiom Plasma level of Fib is positively related with the degree of periventricular hyperintensity in subcortical vascular dementia.