| 前列腺雄激素受体亚型的表达及在前列腺内外带的分布 |
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| 引用本文： | 郝刚跃,马庆铮,许纯孝. 前列腺雄激素受体亚型的表达及在前列腺内外带的分布[J]. 山东大学学报(医学版), 2001, 39(2): 141-142 |
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| 作者姓名： | 郝刚跃 马庆铮 许纯孝 |
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| 作者单位： | 山东大学第二医院泌尿外科;山东省立医院泌尿外科 |
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| 摘 要： | 研究雄激素受体(AR)亚型在前列腺组织中的表达及内外带分布。方法采用聚丙烯酰胺凝胶等电聚焦电泳(IEF)技术,检测了前列腺组织标本20例。结果前列腺组织有3种AR亚型,等电点(PI)分别在6.5、6.0和5.3,3种亚型均表达13例,占65％,所有标本均表达PI6.5亚型;前列腺内带和外带均有3种亚型表达,个体间存在差异;定量分析表明,前列腺内外带AR含量,外带高于内带,但无统计学意义(P>0.05),PI6.0亚型浓度在外带明显高于内带(P<0.05)。结论前列腺AR存在亚型并且具有带性分布特征。
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| 关 键 词： | 前列腺 受体 雄激素 电泳 聚丙烯酰胺凝胶 |
| 文章编号： | 1000-0496(2001)02-0141-02 |
| 修稿时间： | 2000-05-18 |
EXPRESSION OF AR SUBGROUPSAND DISTRIBUTION BETWEEN INTERNAL AND EXTERNAL ZONES IN PROSTATE |
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| HAO Gang-yue,VMA Qing-zheng,XU Chun-xiao. EXPRESSION OF AR SUBGROUPSAND DISTRIBUTION BETWEEN INTERNAL AND EXTERNAL ZONES IN PROSTATE[J]. Journal of Shandong University:Health Sciences, 2001, 39(2): 141-142 |
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| Authors: | HAO Gang-yue VMA Qing-zheng XU Chun-xiao |
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| Abstract: | Objective:To investigate expression of androgen receptor (AR) subgroups in prostate tissue and the distribution of AR subgroups between internal and external zones of prostate.Methods:Expression of AR subgroups in prostate tissue was detected with isoelectric focusing electrophoresis,.Results:There were three radioactive peaks focusing at PI 6.5 ,6.0 and 5.3 in prostate tissue.There were 13 samples(65%) having all three subgroups and PI 6.5 subgroup was detected in all samples.All three subgroups were expressed in both external and internal zones.Although the levels of AR were not significantly different in two zones(P>0.05),the concentration of PI 6.0 subgroup was higher in external zone than that in internal zone(P<0.05).Conclusion:There were AR subgroups in prostate tissue and their distribntion in the zones is different. |
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| Keywords: | Prostate Receptors androgen Electrophoresis polycrylamide gel |
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