Predictors of Thrombosis in Hepatic Vasculature during Microwave Tumor Ablation of an In Vivo Porcine Model |
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| Affiliation: | 1. Department of Radiology, University of Wisconsin, 1111 Highland Avenue, WIMR 1310-O, Madison, WI 53705;2. Department of Biomedical Engineering, University of Wisconsin, 1111 Highland Avenue, WIMR 1310-O, Madison, WI 53705;1. Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD;2. Department of Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD;3. Department of Medical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD;4. Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD;5. Department of Interventional Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD;1. Department of Diagnostic and Interventional Imaging, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France;2. Department of HepatoGastroenterology and Digestive Oncology, Hôpital Saint-André, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France;3. Department of Diagnostic and Interventional Imaging, Hôpital Haut-Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France;4. Institut de Mathématiques de Bordeaux, Unité Mixte de Recherche 5251, Centre National de Recherche Scientifique/Universitaire de Bordeaux, Talence, France;1. Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei;2. Department of Medical Imaging, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100, Taiwan;3. Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100, Taiwan;4. Department of Medical Imaging, National Taiwan University Hospital Yun Lin Branch, Yun-Lin, Taiwan.;1. Laboratory for Minimally Invasive Tumor Therapies, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, WCC 308-B, Boston, MA 02215;2. Division of Image-guided Therapy and Interventional Oncology, Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel;3. Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts;1. Department of Radiology, University of Chicago Medicine, 5841 S. Maryland Ave., MC 2026, Chicago, IL 60636;2. Wright State University Boonshoft School of Medicine, Dayton, Ohio |
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| Abstract: | ![]()
PurposeTo evaluate and model the risk of in vivo thrombosis in each hepatic vessel type during hepatic microwave ablation as a function of vessel diameter, velocity, and vessel-antenna spacing.Materials and MethodsA single microwave ablation antenna was inserted into a single porcine lobe (n = 15 total) adjacent to a hepatic artery, hepatic vein, or portal vein branch. Conventional ultrasound and Doppler ultrasound were used to measure the vessel diameter, blood flow velocity, and vessel-antenna spacing. A microwave ablation zone was created at 100 W for 5 minutes. Thrombus formation was evaluated on ultrasound performed immediately after the procedure. Logistic regression was used to evaluate the predictive value of vessel diameter, blood flow velocity, and vessel-antenna spacing on vascular thrombosis.ResultsThrombosis was identified in 53% of portal veins, 13% of hepatic veins, and 0% of hepatic arteries. The average peak blood flow rate of the hepatic artery was significantly greater than the average peak blood flow rate of the hepatic vein and portal vein. Peak blood flow velocity < 12.45 cm/s, vessel diameter < 5.10 mm, and vessel-antenna spacing < 3.75 mm were strong predictors of hepatic vein thrombosis. However, these individual factors were not predictive of the more common portal vein thrombosis.ConclusionsHepatic arteries do not appear to be at risk for thrombosis during microwave ablation procedures. Portal vein thrombosis was more common than hepatic vein thrombosis during microwave ablation treatments but was not as predictable based on vessel diameter, flow velocity, or vessel-antenna spacing alone. |
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| Keywords: | ROC" },{" #name" :" keyword" ," $" :{" id" :" key0010" }," $$" :[{" #name" :" text" ," _" :" receiver operator characteristic |
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