头孢曲松耐药淋病奈瑟菌株FC428的流行、耐药机制及应对策略

淋球菌耐药问题是性传播疾病防控中面临的巨大挑战,近年来在世界范围包括我国流行的头孢曲松耐药淋病奈瑟菌株FC428使耐药问题更加严峻。该菌株因含新型镶嵌结构的penA基因而对头孢曲松高度耐药,且已在全球广泛传播。为更好地了解FC428的特征,控制其进一步传播,本文综述其起源、传播、主要分子特征、耐药机制、检测方法以及临床治疗和耐药监测的策略。

Ceftriaxone-resistant Neisseria gonorrhoeae strain FC428: prevalence,resistance mechanisms and control strategies

【Abstract】 Antimicrobial resistance of Neisseria gonorrhoeae has become a big challenge in the control and prevention of sexually transmitted diseases. Recently, a ceftriaxone-resistant Neisseria gonorrhoeae strain FC428 has spread across the world including China, which has worsened the antimicrobial resistance problem. This strain is highly resistant to ceftriaxone due to a novel mosaic penA gene. In order to better understand the characteristics of FC428 and control its further spread, this review summarizes its origin, spread, main molecular characteristics, resistance mechanisms, detection methods, and strategies for clinical treatment and antimicrobial resistance surveillance.