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| 神经梅毒发病的危险因素及预测因素研究进展 | |
| 引用本文： | 李可 王千秋 龙福泉. 神经梅毒发病的危险因素及预测因素研究进展[J]. 中华皮肤科杂志, 2021, 54(5): 459-462. DOI: 10.35541/cjd.20200191 |
| 作者姓名： | 李可 王千秋 龙福泉 |
| 作者单位： | 1上海市皮肤病医院性病科200443；2中国医学科学院、北京协和医学院皮肤病研究所，南京210042 |
| 基金项目： | 国家自然科学基金（81772209）；上海市科学技术委员会西医临床引导项目（18411969600）；中国医学科学院医学与健康科技创新工程项目（2016-I2M-3021） |
| 摘 要： | 神经梅毒是梅毒螺旋体侵犯神经系统而导致的较严重的临床阶段，伴或不伴HIV感染的梅毒患者发生神经梅毒的危险因素及预测因素有所不同。HIV阴性梅毒患者发生神经梅毒的危险因素主要包括性别、年龄、梅毒感染阶段、治疗情况等；预测因素包括血清学滴度、脑脊液一些指标的变化及是否伴有神经系统或眼科症状等。HIV病毒载量及CD4 ... |
| 关 键 词： | 神经梅毒 危险因素 HIV 梅毒血清诊断 预测因素 |
| 收稿时间： | 2020-02-28 |
Risk factors and predictors of neurosyphilis |
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| Li Ke,Wang Qianqiu,Long Fuquan. Risk factors and predictors of neurosyphilis[J]. Chinese Journal of Dermatology, 2021, 54(5): 459-462. DOI: 10.35541/cjd.20200191 | |
| Authors: | Li Ke Wang Qianqiu Long Fuquan |
| Affiliation: | 1Department of Sexually Transmitted Disease, Shanghai Skin Disease Hospital, Shanghai 200443, China; 2Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China |
| Abstract: | 【Abstract】 Neurosyphilis is a serious clinical stage of syphilis caused by Treponema pallidum invading the nervous system, and risk and predictive factors of neurosyphilis are different between syphilis patients with and without HIV infection. The risk factors for neurosyphilis in HIV-negative patients with syphilis mainly include gender, age, clinical stage of syphilis, treatment, etc.; the predictive factors include serological titers, changes in some indicators of cerebrospinal fluid, neurological or ophthalmic symptoms. HIV viral load, CD4+ T cell counts and antiretroviral treatment are the main predictors and risk factors for neurosyphilis in HIV-positive patients with syphilis. |
| Keywords: | Neurosyphilis Risk factors HIV Syphilis serodiagnosis Predictive factors |
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