Panayiotopoulos syndrome with convulsive status epilepticus at the onset: A long-term study |
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| Institution: | 1. Department of Pediatrics, University of Perugia, Perugia, Italy;2. Department of Pediatrics, University of Chieti, Chieti, Italy;3. Pediatric Neuropsychiatric Division, “Spedali Civili”, Brescia, Italy;4. Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Institute “Gaslini”, University of Genova, Genova, Italy;5. Neurology Unit, Department of Neuroscience, “Sant’Anna” Hospital, Como, Italy;6. Neuropsychiatry Unit, Department of Pediatrics, University of Bologna, Bologna, Italy;7. Child Neurology, Chair of Pediatrics, II Faculty of Medicine, University of Rome, Rome, Italy;8. Epilepsy Unit, Child Neuropsychiatry Department, University Hospital, Cagliari, Italy;9. Division of Child Neurology, Department of Pediatrics, University “La Sapienza” Rome, Rome, Italy;10. Epilepsy Center, San Paolo Hospital, University of Milan, Milan, Italy;11. Department of Pediatrics, University of Siena, Siena, Italy |
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| Abstract: | PurposeTo better define the convulsive status epilepticus (CSE) as a possible manifestation at the onset of Panayiotopoulos syndrome (PS) and to assess its prognostic value in these children.MethodsChildren with CSE and diagnostic criteria of PS were identified, followed clinically and compared with a group of patients with PS without CSE from 1993 to 2012.ResultsWe identified 37 patients with CSE at the onset of PS. During the same period we identified 72 children with autonomic symptoms of PS without CSE. The first episode of CSE occurred at a mean age of 6.5 years. Generalized clonic seizures were the most common ictal event and one-third of the patients required admission to Intensive Care Units. Interictal EEGs showed occipital spike activity in 31 (83.7%) subjects. Only 14 (37.8%) patients were treated with valproic acid and for two of them (5.40%) it was necessary to administer other drugs. There were no intractable cases. The overall prognosis was excellent. After the first event, 15 subjects (40.54%) experienced at least another typical PS seizure, but all patients were seizure free at the last follow-up.ConclusionCSE is not uncommon in PS and it may occur at the onset of benign childhood epilepsy, without leading to a poor prognosis. |
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| Keywords: | Panayiotopoulos syndrome Generalized clonic seizures Convulsive status epilepticus Occipital spikes |
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