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| 氯沙坦及其代谢物在汉族朝鲜族和维吾尔族健康人体的药动学比较 | |
| 引用本文： | 杨璐,郭涛,夏东亚,曾平. 氯沙坦及其代谢物在汉族朝鲜族和维吾尔族健康人体的药动学比较[J]. 解放军药学学报, 2011, 27(5): 419-421,424. DOI: 10.3969/j.issn.1008-9926.2011.05.013 |
| 作者姓名： | 杨璐 郭涛 夏东亚 曾平 |
| 作者单位： | 1. 110016 辽宁沈阳,沈阳军区总医院药剂科;110016 辽宁沈阳,沈阳药科大学 2. 沈阳军区总医院药剂科, 辽宁沈阳,110016 3. 兰州军区乌鲁木齐总医院药剂科, 新疆乌鲁木齐,830000 |
| 基金项目： | 全军医学科学技术研究“十一五”计划科技攻关课题基金资助项目,No.06G023 |
| 摘 要： | 目的 研究中国汉族、朝鲜族和维吾尔族健康受试者单剂量口服氯沙坦钾片后原形药物及代谢产物的药动学特征.方法 健康受试者30名(其中汉族、朝鲜族、维吾尔族各10名,男女各半),口服单剂量氯沙坦钾片50 mg;用高效液相荧光法测定氯沙坦及其代谢物E-3174血药浓度,DAS2.0软件程序进行数据处理并采用SPSS13.0软件... |
| 关 键 词： | 氯沙坦 E-3174 高效液相荧光检测法 汉族 朝鲜族 维吾尔族 药动学 |
Comparative Pharmacokinetics of Losartan and its Metabolite in Han Korean and Uigur Healthy Subjects |
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| YANG Lu,GUO Tao,XIA Dong-ya,ZENG Ping. Comparative Pharmacokinetics of Losartan and its Metabolite in Han Korean and Uigur Healthy Subjects[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2011, 27(5): 419-421,424. DOI: 10.3969/j.issn.1008-9926.2011.05.013 | |
| Authors: | YANG Lu GUO Tao XIA Dong-ya ZENG Ping |
| Affiliation: | ③ ①Department of Pharmacy,The General Hospital of Shenyang Military Region,Shenyang 110016,China; ②Shenyang Pharmaceutical University,Shenyang 110016,China; ③Department of Pharmacy,The General Hospital of Urumqi,Lanzhou Military Region,Urumqi 830000,China |
| Abstract: | Objective To investigate the pharmacokinetics of losartan and its active metabolite E-3174 after a single oral dose in health voluteers of three different Chinese ethnicities(Han,Korean and Uigur).Methods Thirty healthy subjects(five males and five females of each ethnicity) were recruited and each received a 50mg dose of losartan in the tablet form.The concentration of losartan and its metabolite E-3174 in plasma was determined by high-performance liquid chromatography-fluorescence(high performance liquid ... |
| Keywords: | losartan E-3174 high performance liquid chromatography-FLU Han Korean Uigur pharmacokinetics |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |