ACE基因I/D和ACE2基因A9570G多态性与心房颤动的相关性研究

目的研究血管紧张素转换酶(ACE)基因I/D和血管紧张素转换酶2(ACE2)基因A9570G多态性与心房颤动(简称房颤)的相关性。方法按入院先后顺序入选305例患者,其中房颤患者148例(房颤组),基础疾病与房颤患者匹配的非房颤患者157例(对照组),通过聚合酶链反应-限制性片段长度多态性(PCR-RFLP)和基因测序方法检测两组患者的ACE基因I/Dey ACE2基因A9570G多态性的基因型。结果房颤组ACE基因I/D基因型及等位基因分布与对照组无统计学差异(P=0.841;OR=0.948,95%CI 0.680~1.322,P=0.755),且不同I/D基因型患者的左房前后径和右房横径大小均无统计学差异(P=0.887,P=0.664)。在男性人群中,ACE2基因A9570G基因型分布与对照组比较无统计学差异(OR=1.631,95%CI 0.880~3.023,P=0.119),但在男性房颤患者中,G基因型的左房前后径及右房横径(分别为40.1±6.4、40.1±5.7mm)明显大于A基因型患者(分别为37.0±4.4、36.5±4.4mm),差异有统计学意义(P=0.028,P=0.010);在女性人群中,ACE2基因A9570G基因型及等位基因分布与对照组比较均无统计学差异(P=0.286;OR=1.415,95%CI 0.885~2.264,P=0.146),在女性房颤患者中,ACE2基因A9570G不同基因型的左房前后径和右房横径大小均无统计学差异(P=0.924,P=0.432)。结论 ACE基因I/D和ACE2基因A9570G多态性与房颤的相关性均不明显。但在男性房颤患者中,ACE2基因A9570G多态性中G基因型可能是预测心房增大的一个危险因子。

Correlation between polymorphism of ACE gene I/D and ACE2 gene A9570G and atrial fibrillation

Objective To investigate the correlation between the polymorphism of angiotensin converting enzyme(ACE) gene I/D and angiotensin converting enzyme 2(ACE2) gene A9570G and atrial fibrillation.Methods In chronological order of hospitalization,305 patients were selected and divided into two groups: atrial fibrillation group(148 cases) and control group(157cases without atrial fibrillation).The control group was matched with the atrial fibrillation group in terms of age,gender,and presence of left ventricular d...