正常老年人视空间任务的fMRI研究

目的　探讨正常老年人进行fMRI实验的可行性及视空间任务的激活脑区。方法　对 11例正常老年志愿者进行视空间任务的fMRI实验 ,以SPM99作后处理显示激活脑区。结果　 11例被试的视空间任务均完成较好 ,激活区域主要集中在左侧顶内沟周围皮质、左前额叶的背外侧皮层和双侧枕叶 ,任务相关的特定区域为左侧顶上小叶。结论　老年人进行fMRI实验具有可行性 ,左侧顶上小叶为视空间信息加工的特异性脑区

The Feasibility of fMRI in Visuospatial Task of Aged People

Objective To investigate the feasibility and cortex activation of fMRI in the aged volunteers during the performance of visuospatial tasks. Methods Visuospatial tasks were conducted in 11 normal aged volunteers. The fMRI data was postprocessed using SPM99 to reveal the activated cortex.Results The visuospatial tasks were fulfilled satisfactorily in all aged subjects. Cortex around the left intraparietal sulcus, dorsolateral cortex in the left prefrontal lobe and bilateral occipital lobes showed activation. We found a selective enhancement of fMRI signal in the left superior parietal lobule. Conclusion FMRI tasks are feasible in the aged people and the left superior parietal lobule is the specific in the visuospatial information processing.