| 重组睫状神经营养因子对周围神经再生中多种细胞的作用 |
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| 引用本文： | 许家军,陈尔瑜,路长林,姜宗来,何成. 重组睫状神经营养因子对周围神经再生中多种细胞的作用[J]. 神经解剖学杂志, 2002, 18(4): 355-357,T074 |
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| 作者姓名： | 许家军 陈尔瑜 路长林 姜宗来 何成 |
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| 作者单位： | 第二军医大学解剖学教研室,上海,200433;第二军医大学神经生物学教研室,上海,200433 |
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| 摘 要： | 为了解重组睫状神经营养因子 ( CNTF)对周围神经再生中多种细胞的作用 ,用硅管套接切断的成年大鼠坐骨神经 ,在受损神经局部一次性给予重组睫状神经营养因子 :用免疫组织化学 ABC法结合计算机图像分析观测再生神经中 GAP-4 3、S10 0、CD68、MHC- 免疫反应阳性物质的变化。与生理盐水对照组相比 ,证明 CNTF组再生神经中上述四种物质显著增多。结果提示重组睫状神经营养因子能促进轴突的再生、Schwann细胞的迁入、单核细胞的渗出和活化
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| 关 键 词： | 睫状神经营养因子 神经再生 轴突 Schwann 细胞 单核细胞 周围神经 大鼠 |
EFFECTS OF RECOMBINANT CILIARY NEUROTROPHIC FACTOR ON THE VARIED CELLS DURING PERIPHERAL NERVE REGENERATION |
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| Xu Jiajun,Chen Eryu,Lu Changlin,Jiang Zonglai,He Cheng. EFFECTS OF RECOMBINANT CILIARY NEUROTROPHIC FACTOR ON THE VARIED CELLS DURING PERIPHERAL NERVE REGENERATION[J]. Chinese Journal of Neuroanatomy, 2002, 18(4): 355-357,T074 |
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| Authors: | Xu Jiajun Chen Eryu Lu Changlin Jiang Zonglai He Cheng |
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| Abstract: | To study the effects of recombinant ciliary neurotrophic factor on the varied cells during peripheral nerve regeneration, sciatic nerve of rat was resected and sutured into silicone tube with local infusion of recombinant ciliary neurotrophic factor. The changes of GAP-43, S100, CD68 and MHC-Ⅱ immunoreactivity in the regenerative nerves were observed and measured by immunohistochemical ABC method with computer image analysis. There was more immunoreactivity aforementioned in the regenerative nerves in CNTF group than that in SAL group. The results suggest that recombinant ciliary neurotrophic factor promote axon regeneration, Schwann cell migration, monocyte infiltration and activation. |
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| Keywords: | recombinant ciliary neurotrophic factor nerve regeneration axon Schwann cell monocyte peripheral nerve rat |
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