| 原发性眼内淋巴瘤 |
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| 引用本文： | 胡悦东,陈蕾.原发性眼内淋巴瘤[J].国际眼科杂志,2008,8(3):584-587. |
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| 作者姓名： | 胡悦东 陈蕾 |
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| 作者单位： | 中国医科大学第一附属医院眼科,中国辽宁省沈阳市,110001 |
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| 摘 要： | 原发性眼内淋巴瘤是一种少见的眼部恶性肿瘤,其淋巴瘤病理分类为结节外型弥漫型大细胞B细胞淋巴瘤,属于原发性中枢系统淋巴瘤(PCNSL)的一种。近年来发病率逐渐上升,在过去的20a里,美国PCNSL的发病率增长了3倍。该病临床表现无特异性,往往表现为假性葡萄膜炎,玻璃体或病变组织细胞病理学检查是诊断的金标准;但由于玻璃体活检手术,标本保存和病理诊断方法要求较高,所以诊断困难。治疗上主要应用大剂量甲氨蝶呤治疗。由于往往有神经系统受累,预后不佳,随着治疗方法的改进PIOL的平均存活率已经从1~1.5a提高到3a以上。
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| 关 键 词： | 原发性眼内淋巴瘤 原发性中枢系统淋巴瘤 |
| 修稿时间： | 2007年12月20 |
Primary intraocular lymphoma |
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| Yue-Dong Hu,Lei Chen.Primary intraocular lymphoma[J].International Journal of Ophthalmology,2008,8(3):584-587. |
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| Authors: | Yue-Dong Hu Lei Chen |
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| Institution: | Department of Ophthalmology,the First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China |
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| Abstract: | Primary intraocular lymphoma(PIOL)is a type of primary central nervous system lymphoma(PCNSL).It is an infrequent neoplastic masquerade syndrome involving eyes.It typically masks as chronic ocular inflammatory disease that is resistant to corticosteroid therapy.The diagnosis can be challenging,and it requires the immediate processing of ocular biopsy specimens by experienced cytopathologists.Treatment is still a dilemma,current treatment is based on chemotherapy featuring high-dose methotrexate and radiation therapy.Prognosis is poor due to CNS involvement,but newer therapies have had some success in prolonging survival.And future studies are aimed at delineating the underlying tumor biology and thus developing better-targeted therapies. |
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| Keywords: | primary intraocular lymphoma primary central nervous system lymphoma |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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