| 壮骨解毒丸质量标准的研究 |
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| 引用本文： | 王浩江,白克华,孙体健. 壮骨解毒丸质量标准的研究[J]. 山西医科大学学报, 2012, 43(4): 273-275,320 |
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| 作者姓名： | 王浩江 白克华 孙体健 |
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| 作者单位： | 1. 山西医科大学基础医学院化学教研室,太原,030001
2. 山西医科大学药学院 |
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| 摘 要： | 目的建立壮骨解毒丸的质量控制方法。方法采用薄层色谱法(TLC)对壮骨解毒丸中肉桂进行定性鉴别;采用高效液相色谱法(HPLC)测定人参皂苷Rg1的含量。结果 TLC色谱中可以检测到肉桂;人参皂苷Rg1进样量在0.037-0.74 mg/ml范围内与峰面积值呈现良好线性关系(R2=0.999 6);平均回收率为98.68%,RSD为0.72%。结论液相色谱方法简便、准确、重复性好,可用于控制本品质量。
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| 关 键 词： | 壮骨解毒丸 肉桂 人参皂苷Rg1 质量标准 高效液相色谱法 |
Study on quality standard for Zhuanggujiedu pill |
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| WANG Hao-jiang , BAI Ke-hua , SUN Ti-jian. Study on quality standard for Zhuanggujiedu pill[J]. Journal of Shanxi Medical University, 2012, 43(4): 273-275,320 |
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| Authors: | WANG Hao-jiang BAI Ke-hua SUN Ti-jian |
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| Affiliation: | 1 (1Dept of Chemistry,Shanxi Medical University,Taiyuan 030001,China)2College of Pharmacy,Shanxi Medical University) |
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| Abstract: | Objective To establish a method for the quality control of Zhuanggujiedu pill. Methods Cinnamon was identified by thin layer chromatography(TLC).The content of Rg1 was determined by high performance liquid chromatography(HPLC). Results Cinnamon was detected in Zhuanggujiedu pill by TLC.There was a good linear relationship for Rg1 between the input dosage and the peak area in the range of 0.037-0.74 mg/ml(R2=0.999 6).The average recovery was 98.68%(RSD%=0.72%). Conclusion The established HPLC method is simple,accurate with the good reproducibility.It can be used for the quality control of Zhuanggujiedu pill. |
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| Keywords: | Zhuanggujiedu pill cinnamon ginsenoside Rg1 quality standard high performance liquid chromatography |
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