| 肥胖儿童血浆中orexin-A的表达 |
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| 引用本文： | 贾鲲鹏,赵琳,张红霞,庞随军,李元霞.肥胖儿童血浆中orexin-A的表达[J].山西医科大学学报,2012,43(7):525-527. |
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| 作者姓名： | 贾鲲鹏 赵琳 张红霞 庞随军 李元霞 |
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| 作者单位： | 1. 延安大学附属医院儿科,延安,716000
2. 延安大学医学院解剖教研室 |
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| 基金项目： | 延安大学自然科学专项科研基金资助项目(YD2010-02) |
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| 摘 要： | 目的探讨肥胖儿童血浆orexin-A的表达改变及其与BMI的相关性。方法肥胖组儿童48例,检测患儿空腹外周血中orexin-A水平、体重指数(BMI),并与48例性别、年龄匹配的健康儿童(健康对照组)进行比较。分析两组orexin-A水平与BMI的相关性。结果肥胖组儿童血浆orexin-A水平显著低于健康对照组(P<0.05)。两组血浆orexin-A水平均与BMI呈负相关(P<0.01)。结论 orexin-A参与了肥胖儿童机体能量代谢的调节,orexin-A与摄食密切相关。
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| 关 键 词： | orexin-A 肥胖 儿童 BMI |
Expression of plasma orexin-A in obese children |
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| JIA Kun-peng
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ZHAO Lin
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ZHANG Hong-xia
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PANG Sui-jun
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LI Yuan-xia.Expression of plasma orexin-A in obese children[J].Journal of Shanxi Medical University,2012,43(7):525-527. |
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| Authors: | JIA Kun-peng ZHAO Lin ZHANG Hong-xia PANG Sui-jun LI Yuan-xia |
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| Institution: | 1(1Dept of Pediatrics,Affiliated Hospital of Yan’an University,Yan’an 716000,China;2Dept of Human Anatomy,Medical College of Yan’an University) |
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| Abstract: | Objective To explore the expression of plasma orexin-A and its correlation with body mass index(BMI) in obese children.Methods Fasting plasma orexin-A concentration was measured and compared in 48 obese children(obese group) and 48 matched healthy children(healthy control group).The correlation between plasma orexin-A concentration and BMI was analyzed.Results The plasma orexin-A concentration in obese group was significantly lower than that in healthy control group(P<0.05).There was a negative correlation between plasma orexin-A concentration and BMI in both obese children and healthy controls(P< 0.01).Conclusion Orexin-A may be involved in the regulation of energy metabolism in obese children,and plasma orexin-A may be closely related with energy intake. |
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| Keywords: | orexin-A obesity child body mass index |
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