医院获得性肺炎克雷伯菌性肺炎患者脂质过氧化损伤的研究

目的探讨医院获得性肺炎克雷伯菌性肺炎患者体内的氧自由基损伤. 方法对呼吸加强病房20例医院获得性肺炎克雷伯菌性肺炎患者血清脂质过氧化氢(LHP)水平、血清谷胱甘肽过氧化物酶(GSH-PX) 及血清3种超氧化物歧化酶(SOD)进行测定, 并与对照组进行比较. 结果克雷伯菌性肺炎组LHP明显高于健康对照组, 两组比较差异非常显著(t=7.8901, P<0.01);GSH-PX水平明显低于对照组, 两组比较差异非常显著(t=9.9810, P<0.01);SOD T、SOD Cu-Zn、SOD Mn水平明显低于对照组, 两组比较差异非常显著(t=7.8546, t=10.3378, t=5.2179, 均P<0.01). 结论医院获得性肺炎克雷伯菌性肺炎患者体内存在由自由基介导的脂质过氧化损伤,这种脂质过氧化损伤参与了肺炎克雷伯菌性肺炎的病理过程;在治疗中合理使用自由基清除药物可能提高临床疗效.

Free Radical in Patients with Hospital Acquired Klebsiella pneumoniae Pneumonia

OBJECTIVE To study the oxide damage effect of free radical in the patients with hospital acquired Klebsiella pneumoniae pneumonia. METHODS In 20 cases of patient group and 26 cases of control group, the activity of lipid hydroperoxides (LHP), glutathione peroxidase (GSH-PX) as well as three kinds of superoxide dismutase (SOD) in serum were detected and compared. RESULTS In serum, the activity of LHP, GSH-PX in patient group was higher than that of control one (P<0.01). Meanwhile the activity of three kinds of SOD in patient group was lower than in other one (P<0.01). CONCLUSIONS It shows that the peroxide damage is constantly going on in the cases of K. pneumoniae pneumonia, which joined into the injurious progress of ill. And it suggests that to use the drugs reducing free radicals improve the clinical effect.