Prevalence and Prognostic Significance of Neuroendocrine Differentiation in Colorectal Carcinomas |
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| Authors: | Lloyd Ricardo V. Schroeder Georgene Bauman Mitchel D. Krook James E. Jin Long Goldberg Richard M. Farr Gist H. |
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| Affiliation: | (1) Mayo Clinic and Mayo Foundation, Rochester, MN;(2) Siouxland Hematology, Oncology Associates, Sioux City, IA;(3) Duluth Community Clinical Oncology Program, Duluth, MN;(4) Ochsner CCOP, New Orleans, LA;(5) Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, 55905 Rochester, MN |
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| Abstract: | The prognostic significance of neuroendocrine differentiation in colorectal carcinoma is uncertain. We analyzed 289 moderately
differentiated (grades II and III) colorectal carcinomas for neuroendocrine differentiation by immunohistochemistry andin situ hybridization. The tumors were divided into three groups based on the presence of and the numbers of neuroendocrine cells,
with group I having no neuroendocrine cells, group II having <1 positive cell/mm2, and group III with >1 positive cell/mm2.In situ hybridization with probes for chromogranin A and B detected almost twice as many neuroendocrine cells as did immunostaining
with an antibody for chromogranin A. There was no prognostic difference associated with the presence or absence of neuroendocrine
differentiation in this group of moderately differentiated carcinomas. These results indicate that the presence of neuroendocrine
cells detected by expression of chromogranin protein or mRNA does not influence prognosis in moderately differentiated colorectal
carcinomas. |
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| Keywords: | Neuroendocrine cells colorectal carcinoma chromogranin
in situ hybridization |
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