Live births after management of severe OHSS by GnRH antagonist administration in the luteal phase |
| |
| Authors: | TG Lainas IA Sfontouris IZ Zorzovilis GK Petsas GT Lainas E Alexopoulou EM Kolibianakis |
| |
| Affiliation: | 1. Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria;2. Karl Landsteiner Institute for General Gynecology and Experimental Gynecologic Oncology, Vienna 1090, Austria;1. University Women''s Hospital, Division of Gynaecological Endocrinology and Reproductive Medicine, University of Berne, Effingerstrasse 102, 3010 Berne, Switzerland;2. Centro Medico Puerta de Hierro, Boulevard Puerta de Hierro No.5150, Torre C, 5to Piso, Interior 503-C, Colonia Plaza Corporativa Zapopan, Zapopan, Jalsico, C.P. 45116, Mexico;3. Medizin and Service GmbH, Boettcherstrasse 10, 09117 Chemnitz, Germany;1. Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt;2. The Egyptian IVF Center, Maadi, Cairo, Egypt;3. Department of Obsterics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt;1. Discipline of Medical Biochemistry and Chemical Pathology, Howard College Campus, University of KwaZulu-Natal, Durban, South Africa;2. Department of Physiology, School of Medicine, Faculty of Health Sciences, Prinshof Campus, University of Pretoria, South Africa;3. Department of Cardiology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa |
| |
| Abstract: | ![]()
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of ovarian stimulation protocols. Currently, no curative therapy exists and the main preventive option is cycle cancellation. Gonadotrophin-releasing hormone (GnRH) antagonist administration in the luteal phase was recently proposed as a new approach for the management of patients with established severe OHSS. Three polycystic ovarian syndrome patients undergoing IVF treatment developed severe OHSS, diagnosed 6 days after oocyte retrieval. On day 6, the patients underwent blastocyst transfer and received GnRH antagonist for 4 days, combined with luteal phase support using exogenous oestradiol and progesterone. Two patients had successful pregnancies that resulted in births of healthy infants, while one patient had a biochemical pregnancy. In all patients, established severe OHSS regressed to a moderate form of the syndrome, no pregnancy-induced life-threatening OHSS was observed, while a short monitoring period was required at an outpatient level, avoiding the need for patient hospitalization. This is the first report in the literature on GnRH antagonist administration in the luteal phase, combined with embryo transfer and exogenous oestradiol and progesterone supplementation. This novel treatment was effective in the regression of established severe OHSS, and resulted in the birth of healthy infants. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
