| 嗅鞘细胞移植促进大鼠坐骨神经的再生 |
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| 引用本文： | 马玉海,张勇,曹莉,张少成,潘永太,麻文谦,孙来卿,路长林.嗅鞘细胞移植促进大鼠坐骨神经的再生[J].第二军医大学学报,2004,25(3):301-303. |
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| 作者姓名： | 马玉海 张勇 曹莉 张少成 潘永太 麻文谦 孙来卿 路长林 |
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| 作者单位： | 1. 第二军医大学长海医院骨科,上海,200433
2. 第二军医大学基础医学部神经生物学教研室,上海,200433 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 目的:研究嗅鞘细胞(OECs)移植对大鼠坐骨神经再生的作用.方法:30只SD大鼠随机分为OECs组和对照组,每组15只; 切除3 mm右侧坐骨神经并用预先充填可吸收明胶的硅胶管套接修复,OECs组和对照组硅胶管内分别给予体外培养纯化的OECs和生理盐水; 术后4、8和12周分别行电生理和组织学检查.结果:术后4、8和12周,OECs组和对照组修复神经均有不同程度再生,OECs组运动神经传导速度、神经肌肉动作电位幅度、有髓神经纤维数目和直径均明显高于对照组(P<0.05).结论:外源性OECs移植能明显促进大鼠坐骨神经再生.
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| 关 键 词： | 嗅鞘细胞 细胞移植 神经再生 坐骨神经 |
| 文章编号： | 0258-879X(2004)03-0301-03 |
| 修稿时间： | 2003年7月20日 |
Olfactory ensheathing cells transplantation enhancing sciatic nerve regeneration |
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| MA Yu Hai ,ZHANG Yong ,CAO Li ,ZHANG Shao Cheng ,PAN Yong Tai ,MA Wen Qian ,SUN Lai Qing ,LU Chang Lin.Olfactory ensheathing cells transplantation enhancing sciatic nerve regeneration[J].Academic Journal of Second Military Medical University,2004,25(3):301-303. |
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| Authors: | MA Yu Hai ZHANG Yong CAO Li ZHANG Shao Cheng PAN Yong Tai MA Wen Qian SUN Lai Qing LU Chang Lin |
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| Institution: | MA Yu Hai 1,ZHANG Yong 2,CAO Li 2,ZHANG Shao Cheng 1*,PAN Yong Tai 1,MA Wen Qian 1,SUN Lai Qing 1,LU Chang Lin 2 |
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| Abstract: | Objective:To investigate the role of exogenous olfactory ensheathing cells (OECs) in promoting nerve regeneration after sciatic nerve injury in adult rats. Methods: Thirty SD rats were randomly divided into OECs group and control group. A 5 mm gap left by sciatic nerve resection was bridged with a silicone tube prefilled with gelatin. Purified OECs or saline were injected into the tube respectively. On 4,8 and 12 weeks after sciatic nerve repair,nerve regeneration was evaluated by morphology,electrophysiology and histochemistry study. Results: Sciatic nerve regeneration was obtained in all rats after 4,8 and 12 weeks,and the regeneration of OECs group was better than that of control group( P <0.05). Conclusion: Exogenous OECs can obviously enhance peripheral nerve regeneration. |
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| Keywords: | olfactory ensheathing cells cell transplantation nerve regeneration sciatic nerve |
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