| 脑深部电刺激伏核对自身给药大鼠海洛因觅药行为的影响 |
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| 引用本文： | 郭烈美,周洪语,王冉,钟志宏,徐纪文,江基尧,周文华,张富强,唐甩恩,刘惠芬. 脑深部电刺激伏核对自身给药大鼠海洛因觅药行为的影响[J]. 立体定向和功能性神经外科杂志, 2010, 0(2) |
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| 作者姓名： | 郭烈美 周洪语 王冉 钟志宏 徐纪文 江基尧 周文华 张富强 唐甩恩 刘惠芬 |
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| 作者单位： | 上海交通大学医学院附属仁济医院神经外科;浙江宁波戒毒研究中心;宁波大学医学院行为神经科学研究中心; |
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| 基金项目： | 国家自然科学基金面上项目(编号:30600634) |
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| 摘 要： | 目的观察脑深部电刺激(deep brain stimulation,DBS)伏核对大鼠海洛因自身给药觅药行为的影响。方法用固定比率程序建立大鼠海洛因自身给药复吸模型。将18只大鼠随机分成对照组、假刺激组和DBS组,假刺激组及DBS组大鼠行双侧伏核核心部微电极植入术。DBS组大鼠在消退期每天给予高频电刺激1h(刺激参数:方波,频率130 Hz,电流150μA,波宽100μs),共7d。消退后采用条件性线索和小剂量海洛因诱导引燃大鼠海洛因觅药行为。结果在条件性线索诱导的复吸测评中,DBS组大鼠有效鼻触数(8.00±5.33)明显少于对照组(36.50±9.16)和假手术组(34.00±7.93),具统计学意义(P<0.01);在小剂量海洛因诱导的复吸测评中,DBS组大鼠有效鼻触数(11.17±7.78)明显少于对照组(29.67±5.24)和假手术组(28.00±11.92),具统计学意义(P<0.01);DBS组、对照组和假手术组大鼠在总活动度和每阶段活动度上的差异均无统计学意义(P>0.01)。结论DBS高频电刺激伏核可减少海洛因自身给药大鼠条件性线索和小剂量海洛因诱导的觅药行为,且不会影响其活动度。
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| 关 键 词： | 脑深部电刺激 自身给药 条件性线索 伏核 |
Effects of deep brain stimulation of nucleus accumbens on heroin-seeking behavior in self-administration rats |
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| Guo Liemei,Zhou Hongyu,Wang Ran,et al. Effects of deep brain stimulation of nucleus accumbens on heroin-seeking behavior in self-administration rats[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2010, 0(2) |
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| Authors: | Guo Liemei Zhou Hongyu Wang Ran et al |
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| Affiliation: | Guo Liemei,Zhou Hongyu,Wang Ran,et al.Department of Neurosurgery,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai,200127 |
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| Abstract: | Objective To observe effects of deep brain stimulation(DBS) of nucleus accumbens on heroin-seeking behavior in self-administration rats.Methods Self-administration rat models of relapsing in heroin was established with fixed ration program,and model rats were randomly divided into 3 groups: a control group,a sham stimulation group and a DBS group;the rats of sham stimulation group and DBS group were implanted bilaterally with concentric bipolar microelectrodes.The the rats in DBS group were given a 1-hour-l... |
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| Keywords: | Deep brain stimulation Self-administration Conditioned cues Nucleus accumbens |
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