胃肠道间质肿瘤38例临床病理分析

目的:探讨胃肠道间质瘤(gastrointestinal stromal tumors,GIST)的临床病理表现、组织学和免疫组化的特点。方法:对38例GIST患者的临床病理进行回顾性分析,并对其标本采用免疫组化方法检测CD117、CD34、Actin、S-100的表达情况。结果:本组GIST发生于胃部24例(63.2%),小肠11例(28.9%),结直肠3例(7.9%)。良性16例,潜在恶性4例,恶性18例,CD117阳性表达率94.7%(36/38)、CD34阳性率50.0%(19/38)、Actin7.9%(3/38)、S-1002.6%(1/38),且均通过手术治疗。结论:CD117标记阳性是确诊GIST最重要的诊断依据,手术仍是GIST主要治疗手段。

A clinicopathologic study of 38 cases of gastrointestinal stromal tmmors

Objective:To explore the clinical behavior,and morphology,immunohistochemical characteristics of gastrointestinal stromal tumors(GIST) .Methods:Retrospective analysis was performed on 38 GIST patients,based on clinic pathological data between Feb.2000 and Dec.2004,and followed by an immunohistochemical analysis of the specimens using CD117,CD34,Actin,and S-100.Results:Among GIST suffering sites,stomach accounted for 63.2%(24/38) ,small intestine 28.9%(11/38) ,colorectum 7.9%(3/38) .16 cases were benign,4 were potential malignant and 18 were malignant.CD117 positive rate was 95%(36/38) ,50% CD34 positive(19/38) ,7.9% Actin positive(3/38) and 2.8% S-100 positive(1/38) .Conclusion:Positive CD117 marker was the most important proof in final diagnosis of GIST and surgical treatment is still the main method for GIST therapy.