| 热激蛋白60和CXC趋化因子受体2在人胶质瘤细胞中转移和侵袭性的研究进展 |
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| 引用本文： | 刘增辉,杨 柳,顾志恺.热激蛋白60和CXC趋化因子受体2在人胶质瘤细胞中转移和侵袭性的研究进展[J].医学综述,2014(1):41-43. |
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| 作者姓名： | 刘增辉 杨 柳 顾志恺 |
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| 作者单位： | [1]南通大学医学院,江苏南通226001 [2]南通大学附属医院神经外科,江苏南通226001 |
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| 摘 要： | 人脑胶质瘤是成人神经系统最常见的恶性肿瘤,免疫基因治疗已经成为近年来研究热点之一。热激蛋白60(HSP60)和CXC趋化因子受体2(CXCR2)作为两种细胞因子,在胶质瘤细胞的免疫、增殖、转移和侵袭中都具有重要作用。大量研究显示,阻断和抑制HSP60和CXCR2的基因治疗可促进胶质瘤细胞的凋亡,提高胶质瘤的疗效,今后应进一步加强该方面的研究。
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| 关 键 词： | 胶质瘤 热激蛋白60 CXC趋化因子受体2 |
Research Progress of HSP60 and CXCR2 in Metastasis and Invasion of Glioma |
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| Institution: | LIU Zeng-hui , YANG Liu , CU Zhi-kai ( 1. Medical School of Nantong University, Nantong 226001, China ; 2. Department of Neurosurgery,Affiliated Hospital of Nantong University, Nantong 226001, China) |
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| Abstract: | Human glioma is the most common malignant tumor of adult nervous system and immune gene therapy has become one of research hotspots recently. As cytokines, heat shock protein 60 （HSP60）and CXC chemokine receptor 2 （ CXCR2 ） play an important role in immune, proliferation, metastasis and invasion of glioma. More and more studies have shown that blocking and inhibition of HSP60 and CXCR2 can promote the apoptosis of glioma cells and improve the curative effect of the tumor, where further research should be strengthened in the coming future. |
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| Keywords: | Glioma Heat shock protein 60 CXC chemokine receptor 2 |
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