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| 促红细胞生成素促脑血管新生机制研究进展 | |
| 引用本文： | 祝慧凤,徐晓玉,万东,张芬,王红利,薛莉君. 促红细胞生成素促脑血管新生机制研究进展[J]. 中国药理学通报, 2011, 27(4): 451-454. DOI: 10.3969/j.issn.1001-1978.2011.04.003 |
| 作者姓名： | 祝慧凤 徐晓玉 万东 张芬 王红利 薛莉君 |
| 作者单位： | 1. 西南大学药学院暨中医药学院,重庆,400715 2. 重庆医科大学附属第一医院,重庆,400016 |
| 基金项目： | 国家自然科学基金，西南大学博士基金 |
| 摘 要： | 促红细胞生成素(erythropoietin,EPO)是一种糖蛋白激素,是哺乳动物调节红细胞生成所必需的体液性生长因子。新近研究表明EPO具有神经保护和修复功能,其发挥脑保护效应有两条路径:即神经保护和血管新生。该文主要综述了EPO的血管新生效应和机制:EPO能够通过血脑屏障(BBB);EPO促进脑血管新生,效应与VEGF相当,但不增加BBB通透性;EPO动员骨髓内皮祖细胞到外周循环,促进内皮细胞增殖、迁移和管样结构形成,促进新生血管成熟为功能血管;EPO分泌具有可调控性。 |
| 关 键 词： | 促红细胞生成素 血脑屏障 脑血管新生 VEGF 效应 机制 可调控性 |
The role of erythropoietin in regulating angiogenesis in brain |
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| ZHU Hui-feng,XU Xiao-yu,Wan Dong,ZHANG Fen,WANG Hong-li,XUE Li-jun. The role of erythropoietin in regulating angiogenesis in brain[J]. Chinese Pharmacological Bulletin, 2011, 27(4): 451-454. DOI: 10.3969/j.issn.1001-1978.2011.04.003 | |
| Authors: | ZHU Hui-feng XU Xiao-yu Wan Dong ZHANG Fen WANG Hong-li XUE Li-jun |
| Affiliation: | 1(1.School of Pharmaceutical Sciences & School of Chinese Medicine,Southwest University,Chongqing 400715,China; 2.Dept of Emergency,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China) |
| Abstract: | Erythropoietin,hormone produced by the kidney,plays a vital role in the formation of red blood cells by the bone marrow.However,recent studies indicate that EPO also has neuroprotective and repair functions of the brain;it has two paths:nerve protection and angiogenesis.In this paper,pro-angiogenesis effects and its mechanisms of EPO are reviewed:EPO can cross blood-brain barrier(BBB);EPO and VEGF exhibit equal angiogenic potential,but prevents the increase in blood-brain barrier permeability induced by VEGF;EPO can promote endothelial progenitor from marrow to peripheral circulation and enhence endothelial cell proliferation,migration and blood vessel formation and maturation;EPO secretion can be induced. |
| Keywords: | VEGF |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |