| 肿瘤坏死因子体内抗肿瘤活性及其对巨噬细胞激活作用的关系 |
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| 引用本文： | 董海东,邢嵘,郭连英,钱振超.肿瘤坏死因子体内抗肿瘤活性及其对巨噬细胞激活作用的关系[J].大连医科大学学报,1992(1). |
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| 作者姓名： | 董海东 邢嵘 郭连英 钱振超 |
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| 作者单位： | 大连医学院病理生理学教研室，大连医学院病理生理学教研室，大连医学院病理生理学教研室，大连医学院病理生理学教研室 |
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| 摘 要： | 在体外细胞毒活性实验中,小鼠乳腺癌Ca761-86细胞对rTNF不敏感,而在体内,rTNF却可明显抑制Ca761-86细胞的生长。根据(1)rTNF在体外可直接激活小鼠腹腔巨噬细胞杀伤Ca761-86细胞;(2)在体内由rTNF诱导和激活的腹腔和脾脏中的巨噬细胞均可杀伤体外培养的Ca761-86细胞;提示rTNF在体内对Ca761-86细胞的抑制瘤效应与其对巨噬细胞的激活作用也可能有关。
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| 关 键 词： | 肿瘤坏死因子 巨噬细胞 细胞毒活性 |
STUDY ON THE RELATION OF ANTITUMOR ACTIVITY OF TUMOR NECROSIS FACTOR IN VIVO AND ITS ACTIVATION EFFECTS ON MACROPHAGES |
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| Dong Haidong,et al Dept.of Pathophysiology,Dalian Medical college.STUDY ON THE RELATION OF ANTITUMOR ACTIVITY OF TUMOR NECROSIS FACTOR IN VIVO AND ITS ACTIVATION EFFECTS ON MACROPHAGES[J].Journal of Dalian Medical University,1992(1). |
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| Authors: | Dong Haidong Deptof Pathophysiology Dalian Medical college |
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| Abstract: | We investigated the cytotoxic activity of recombinant tumor necrosis factor (rTNF) against Ca761-86 mammary carcinoma both in vitro and in vivo. In direct cytotoxic assay, Ca761-86 cells showed no sensitivity to rTNF. However, rTNF was found to be highly efficacious against subcutaneously implanted Ca761-86 mammary carcinoma.In order to explain this discrepancy, we examined the indirect effects of rTNF on Ca761-86 cells particularly through macrophages, we found that rTNF can directly activated macrophage for killing Ca761-86 cells in vitro. In vivo, peritoneal and splenic macrophages induced and activated by rTNF also showed cytotoxic activity against Ca761-86 calls. This results suggest that rTNF, used in vivo, can induce and activate macrophages to kill tumor cells. |
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| Keywords: | tumor necrosis factor macrophage cytotoxicity |
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