The effect of drugs influencing amine synthesis on the analgesic action of tremorine |
| |
| Authors: | Vimala H. Sethy S. R. Naik U. K. Sheth |
| |
| Affiliation: | (1) Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-12, India;(2) Present address: Department of Pharmacology, School of Medicine, State University of New York, 14214 Buffalo, N.Y.;(3) Pharmacology Research Unit of C.S.I.R., India |
| |
| Abstract: | ![]()
The effect of reserpine,  -methyl-dl-m-tyrosine (-MT), diethyl-dithiocarbamate (DDC) and p-chlorophenylalanine (p-Clphe) pretreatment on tremorine induced analgesia has been studied in mice by various methods. The ED 50 of tremorine was significantly increased by all the methods when the animals were pretreated with reserpine, DDC and p-Clphe. -MT had no significant effect on tremorine induced analgesia. The results are discussed with respect to the role of brain amines in the analgesic action of tremorine. |
| |
| Keywords: | Tremorine Catecholamines 5-Hydroxytryptamine |
| 本文献已被 SpringerLink 等数据库收录！ |
|
