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Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers
Authors:Matthias G. Pauthner  Joseph P. Nkolola  Colin Havenar-Daughton  Ben Murrell  Samantha M. Reiss  Raiza Bastidas  Jérémie Prévost  Rebecca Nedellec  Benjamin von Bredow  Peter Abbink  Christopher A. Cottrell  Daniel W. Kulp  Talar Tokatlian  Bartek Nogal  Matteo Bianchi  Hui Li  Jeong Hyun Lee  Salvatore T. Butera  Dennis R. Burton
Affiliation:1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), The Scripps Research Institute, La Jolla, CA 92037, USA;3. IAVI Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery (CAVD), The Scripps Research Institute, La Jolla, CA 92037, USA;4. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;5. Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA;6. Division of Infectious Diseases, Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA;7. Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada;8. Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montreal, QC H2X 0A9, Canada;9. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA;10. Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;11. Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA;12. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA;13. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;14. Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada;15. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA;16. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;17. Departments of Biological Engineering and Materials Science & Engineering, MIT, Cambridge, MA 02139, USA;18. Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands;19. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA
Abstract:
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  • Keywords:HIV vaccine  vaccination  neutralizing antibodies  correlates of protection  BG505  tier 2 protection  non-human primates  ADCC
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