| Affiliation: | 1. Department of Oral and Maxillofacial Pathology, Ziauddin College of Dentistry, Ziauddin University, 75600 Karachi, Pakistan;2. Department of Pathology, Islamabad Medical & Dental College, 45400 Islamabad, Pakistan;3. Ziauddin College of Dentistry, Ziauddin University, 75600 Karachi, Pakistan;4. Department of Chemical Pathology, Ziauddin University Hospital, 75600 Karachi, Pakistan;5. Department of Oral Biology, Ziauddin College of Dentistry, Ziauddin University, 75600 Karachi, Pakistan;6. Department of Periodontology, Faculty of Dentistry, Ziauddin University, 75600 Karachi, Pakistan |
| Abstract: | ![]()
AimTo investigate the expression of salivary S100A7 levels among patients with oral submucous fibrosis (OSF) and healthy controls.MethodA total number of 60 participants were included in the study (30 OSF cases and 30 healthy controls). Demographic data was collected using a structured baseline questionnaire. Salivary S100A7 levels were quantified using enzyme-linked immunosorbent assay. Data was analyzed using Student t-test. Pearson correlation test was used to evaluate correlation between S100A7 levels and independent variables such as frequency and duration of areca nut use, gutka use, and mouth opening.ResultsThe mean value of salivary S100A7 for OSF group was 0.275?ng/ml, whereas mean value of salivary S100A7 for healthy controls was 0.195?ng/ml. Student t-test indicated that there was statistically significantly higher levels of S100A7 in OSF group as compared to healthy controls (p?p?=?.009) and gutka chewing (p?=?.03), whereas a significant positive correlation was found for mouth opening (p?=?.04).ConclusionOSF presented higher levels of salivary S100A7 levels as compared with healthy individuals and may be used as surrogate measure to identify subjects at risk for OSF. |
