血栓通联合银杏达莫治疗中风后痉挛性偏瘫的疗效研究

目的：探讨血栓通联合银杏达莫对中风后痉挛性偏瘫治疗的临床疗效。方法100例中风后痉挛性偏瘫患者随机分为对照组和治疗组，每组50例。对照组在常规治疗的基础上静脉滴注血栓通，治疗组给予血栓通联合银杏达莫治疗，2组均治疗2个疗程（28 d）后评价疗效，分别于患者入院第1天和第10天对患者进行改良波士顿汉语失语症测试，用MMSE法来测定患者的认知功能，采用神经功能缺损评分（ NIHSS）与Barthel指数对2组患者神经功能缺损及生活能力进行评测。结果治疗组总有效率为98吵．0％，优于对照组的72．0％（ P ＜0．05）；治疗组患者临床神经功能缺损程度评分优于对照组（ P ＜0．05）。治疗组第1天改良波士顿汉语失语症测试评分与对照组第1天评分比较，差异无统计学意义（ P ＞0．05），治疗组第10天改良波士顿汉语失语症评分与对照组第10天评分计较，差异有统计学意义（ P ＜0．05）；2组治疗后1、3、6个月，1年MMSE评分较治疗前有明显下降（ P ＜0．05），各个时间点治疗组MMSE评分显著低于对照组（ P ＜0．05）；治疗组Barthel指数高于对照组，NIHSS评分低于对照组，差异有统计学意义（ P ＜0．05）。结论血栓通联合银杏达莫对中风后痉挛性偏瘫利于患者的语言康复和神经功能的恢复，提高治疗后的认知能力，治疗安全有效。

Therapeutic effects of Xueshuantong injection combined with Yinxingdamo on spastic hemiplegia after cerebral stroke

Objective To observe the therapeutic effects of Xueshuantong injection combined with Yinxingdamo on spastic hemiplegia after cerebral stroke.Methods One hundred patients with spastic hemiplegia after cerebral stroke were randomly divided into control group and the treatment group,with 50 patients in each group.The patients in control group,on the basis of conventional therapy, were treated by intravenous drip with Xueshuantong, however, the patients in treatment group were treated by Xueshuantong injection combined with Yinxingdamo,with 2 treatment courses for 28 days.The improved Boston Chinese aphasia test was performed,and MMSE method was used to determine patient's cognitive function, moreover, The US National Institutes of Health nerve impairment score ( NIHSS) and Barthel indexes were used to evaluate neurologic impairment and living ability of patients.Results The total effective rate in treatment group was 98%,which was significantly higher than that (76%) in control group ( P <0.05) .After treatment, neurologic impairment scores in treatment group were superior to those in control group ( P <0.05).There were no significant differences in improved Boston Chinese aphasia test scores on 1 day after treatment between two groups ( P >0.05),however, there were significant differences in improved Boston Chinese aphasia test scores on 10 day after treatment between two groups ( P <0.05).The MMSE scores on 1m, 3m, 6m and 1 year after treatment were significantly decreased in both groups,as compared with those before treatment ( P <0.05),however, MMSE scores in treatment group in different time points were significantly lower than those in control group ( P<0.05 ) .After treatment, Barthel indexes in treatment group were significantly higher than those in control group, however, NIHSS scores were significantly lower than those in control group ( P <0.05 ) .Conclusion Xueshuantong injection combined with Yinxingdamo can improve the language rehabilitation and neurologic function recovery of patients with spastic hemiplegia after cerebral stroke, moreover,which can improve patient’ s cognitive abilities, with better therapeutic effects and safety.