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| 硫酸皮肤素衍生物对大鼠肥大细胞脱颗粒的影响 | |
| 引用本文： | 杜海燕,姬胜利,曹吉超. 硫酸皮肤素衍生物对大鼠肥大细胞脱颗粒的影响[J]. 中国生化药物杂志, 2003, 24(5): 217-219 |
| 作者姓名： | 杜海燕 姬胜利 曹吉超 |
| 作者单位： | 山东大学,药学院,生化与生物技术药物研究所,山东,济南,250012 |
| 基金项目： | 山东省自然基金资助项目 (Y2 0 0 0C2 2 ) |
| 摘 要： | 目的研究不同来源不同分子量的低分子硫酸皮肤素 (LMWDS)及多硫酸化硫酸皮肤素 (PSDS)对大鼠肥大细胞 (MC)脱颗粒的影响。方法通过大鼠腹腔被动MC脱颗粒实验 ,观察LMWDS及PSDS对卵清蛋白引起MC脱颗粒的影响。结果与Hank液组比较 ,硫酸皮肤素衍生物均能明显抑制MC脱颗粒 ;与色甘酸钠组比较 ,PSDS组、牛肺来源的BLMWDS 3组和猪肠来源的PLMWDS 3组有显著的抑制MC脱颗粒作用。PSDS、BLMWDS、PLMWDS抑制MC脱颗粒作用与剂量呈正相关。结论硫酸皮肤素衍生物具有抑制MC脱颗粒作用 ,该作用与其分子量大小及结构有关 |
| 关 键 词： | 低分子硫酸皮肤素 多硫酸化硫酸皮肤素 肥大细胞 脱颗粒 |
| 文章编号： | 1005-1678(2003)05-0217-03 |
| 修稿时间： | 2003-04-08 |
Effects of dermatan sulfate derivatives on rat mast cell degranulation |
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| DU Hai-yan,JI Sheng-li,CAO Ji-chao. Effects of dermatan sulfate derivatives on rat mast cell degranulation[J]. Chinese Journal of Biochemical Pharmaceutics, 2003, 24(5): 217-219 | |
| Authors: | DU Hai-yan JI Sheng-li CAO Ji-chao |
| Abstract: | PurposeTo study the effects of low molec ular weight dermatan sulfate oligosaccharides from different origins and poly-sulfa ted dermatan sulfate on rat mast cell degranulation.Methods Using the method of passive mast cell degranulation induced by ovalbumin in r ats to observe the effects of different molecular weight dermatan sulfate oligos accharides from different origins and poly-sulfated dermatan sulfate on mast ce ll degranulation.ResultsCompared with Hank solution grou p, all DS derivatives could obviously inhibit MC degranulation. Compared with sodium crom oglicate group, PSDS, BLMWDS-3 (from bovine lungs) and PLMWDS-3 ( from pig int estines) could significantly inhibit the degranulation of abdominal mast cell in rats. The inhibition of PSDS, BLMWDS-3 and PLMWDS-3 was positively related to their dosage.ConclusionDS derivatives inhibit MC degran ulation, and the activities are related to their molecular size and structure. |
| Keywords: | low molecular weight dermatan sulfate poly-sulfate d dermatan sulfate mast cell degranulation |
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