| IL-8和IL-12与急性胰腺炎分类的探讨 |
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| 引用本文： | 艾迎春,韩桂华,郭公新,陈福军.IL-8和IL-12与急性胰腺炎分类的探讨[J].黑龙江医药科学,2004,27(1):34-35. |
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| 作者姓名： | 艾迎春 韩桂华 郭公新 陈福军 |
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| 作者单位： | 佳木斯大学第一临床医院,黑龙江,佳木斯,154002;佳木斯大学第一临床医院,黑龙江,佳木斯,154002;佳木斯大学第一临床医院,黑龙江,佳木斯,154002;佳木斯大学第一临床医院,黑龙江,佳木斯,154002 |
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| 摘 要： | 目的 :探讨重症胰腺炎的发病机制和早期监测指标。方法 :用 EL ISA方法测定 10例重型胰腺炎 (SAP) ,18例轻型胰腺炎 (MAP)和 10例正常健康者 (N)血清中 IL- 8及 IL- 12含量。结果 :SAP组 IL- 8,IL- 12水平明显高于 MAP组(P<0 .0 1) ,MAP组 IL- 8明显高于 N组 (P <0 .0 1) ,MAP组 IL- 12明显低于 N组 (P <0 .0 1) ,但 SAP组与 N组比较无差异 (P >0 .0 5 )。结论 :提示在急性胰腺炎发病过程中 ,既存在抗炎反应又存在促炎反应 ,两者的结果与病变的严重程度一致
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| 关 键 词： | 急性胰腺炎分类 白细胞介素-8 白细胞介素-12 |
| 文章编号： | 1008-0104(2004)01-0034-02 |
| 修稿时间： | 2003年10月15 |
IL-8, LL-12 and acute pancreatitis classification |
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| AI Ying-chun,HAN Gui-hua,GUO Gong-xin,CHEN Fu-jun.IL-8, LL-12 and acute pancreatitis classification[J].Heilongjiang Medicine and Pharmacy,2004,27(1):34-35. |
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| Authors: | AI Ying-chun HAN Gui-hua GUO Gong-xin CHEN Fu-jun |
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| Abstract: | Objective: To explore the phathogenesis and early monitoring criteria of severe acute pancreatitis(SAP).Methods: The level of interleukin-8(IL-8) and interleukin-12(IL-12) in peripheral blood were measured by enzyme linked immunosorbent assay(ELISA) in 10 SAP patients, 18 mild acute pancreatitis(MAP) patients and 10 normal subjects (N).Results: The blood levels of IL-8 and IL-12 in SAP patients were significantly higher than those in MAP patients (P<0.01), and the blood levels of IL-8 in MAP patients were significantly higher than those normal subjects(P<0.01),and whereas the blood level of IL-12 was significantly lower than that of the control (P<0.01),with no difference between the SAP patients and the normal subjects (P>0.05). Conclusion: There were pro-and anti-inflammatory responses during the development of the acute pancreatitis. Both of results were closely related to the severity degree of the disease. |
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| Keywords: | acute pancreatitis classification interleukin-8 interleukin-12 |
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