| 花椒超临界萃取物对豚鼠离体气管活动的影响 |
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| 引用本文： | 张玉祥,曾晓会,周瑞玲,陈玉兴,崔景朝. 花椒超临界萃取物对豚鼠离体气管活动的影响[J]. 中药新药与临床药理, 2006, 17(1): 13-15 |
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| 作者姓名： | 张玉祥 曾晓会 周瑞玲 陈玉兴 崔景朝 |
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| 作者单位： | 1. 广东化工制药职业技术学院,广州,510200
2. 广东省中医研究所,广州,510095 |
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| 摘 要： | 目的探讨花椒超临界萃取物（HJ）对豚鼠离体气管的作用及其机制。方法通过HJ对正常气管、乙酰胆碱（Ach）所致气管痉挛及磷酸组胺（HIS）致气管依内、外钙两种收缩的影响，初步探讨HJ对离体气管的作用及其机制。结果HJ对正常气管、Ach和HIS所致气管痉挛及HIS致气管依外钙收缩有明显的抑制作用，并呈剂量依赖性。结论HJ有平喘的作用。
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| 关 键 词： | 花椒 超临界萃取 豚鼠 离体气管 作用机制 |
| 文章编号： | 1003-9783（2006）01-0013-03 |
| 收稿时间： | 2005-11-10 |
| 修稿时间： | 2005-11-10 |
Effect of Supercritical Fluid Carbon Dioxide Extracts from Pericarpium Zanthoxyli on in- Vitro Activity of Guinea Pig Trachea |
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| ZHANG Yuxiang,ZENG Xiaohui,ZHOU Ruiling,CHENG Yuxing,CUI Jingchao. Effect of Supercritical Fluid Carbon Dioxide Extracts from Pericarpium Zanthoxyli on in- Vitro Activity of Guinea Pig Trachea[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2006, 17(1): 13-15 |
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| Authors: | ZHANG Yuxiang ZENG Xiaohui ZHOU Ruiling CHENG Yuxing CUI Jingchao |
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| Affiliation: | 1. Guangdong Occupation Technology College of Chemistry Engineering and Pharmacy, Guangzhou 510200; 2. Guangdong Institute of Traditional Chinese Medicine, Guangzhou 510095 |
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| Abstract: | Objective To investigate the effect of Pericarpium Zanthoxyli (HJ) on guinea pigs trachea in vitro and its therapeutic mechanism. Methods The actions of HJ on the contraction of normal trachea and on the spasm of spasmodic tracheas caused by acetylcholine (Ach) and histamine phosphate (HIS), as well as the actions on intracellular Ca2+ - dependent contraction and extracellular Ca2+ - dependent contraction induced by HIS were observed. Results HJ could inhibit the guinea pigs trachea contraction , antagonize the contraction of trachea spasm induced by Ach and HIS , restrain the extracellular Ca2+ - dependent contraction induced by HIS in a dose- dependent manner. Conclusion HJ has an antiasthma effect. |
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| Keywords: | Pericarpium Zanthoxyli Supercritical fluid extraction Guinea pigs Trachea in vitro Therapeutic mechanism |
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