高压氧联合甲钴胺治疗糖尿病周围神经病变的疗效

目的 评价高压氧联合甲钴胺对糖尿病周围神经病变的疗效,探讨治疗糖尿病周围神经病变的有效方法.方法 378例糖尿病周围神经病变患者分为2组.治疗组198例,予高压氧联合甲钴胺治疗,高压氧疗法采用大型空气加压舱,治疗压力为0.2 Mpa(2.0 ATA),每日1次;甲钴胺500 μg,肌肉注射,每日1次.对照组180例,单独使用甲钴胺500 μg,肌肉注射,每日1次.2组患者疗程均为4周.结果 治疗组显效率、总有效率分别为40.9%和100%,明显高于对照组的17.3%及53.3%,2组间差异有统计学意义(P＜0.01);治疗组神经传导速度及血流动力学改善均明显高于对照组(P＜0.01).结论 高压氧联合甲钴胺对糖尿病周围神经病变的治疗效果显著,总有效率为100%,可作为糖尿病周围神经病变的常规治疗方法.

Effects of therapy of hyperbaric oxygen combined with mecobalamin on diabetic peripheral neuropathy

Objective To study effects of hyperbaric oxygen combined with mecobalamine on diabetic peripheral neuropathy(DPN)and explore effective therapeutic way to DPN.Methods Three hundred and seventy-eight patients.were divided into two groups.The treatment group(198 cases)were treated with hyperbaric oxygen(HBO)and mecobalamin(0.2 MPa,500 μg mecobalamin i.m.,once a day).The control group(180 cases)were only treated with 500 μg meeobalamin i.m.,once a day.Courses of treatment in two groups both were four weeks.Results The effective rate and overall efficacy rate of treatment group were 40.9% and 100%,respectively.They were significantly higher than those of control group(17.3% and 53.3%)(P＜0.01).At the same time,there were obvious differences in nerve conduction velocity and dvnamics of blood flow between two groups(P＜0.01).Conclusions HBO combined with mecobalamin has therapeutic effect on DPN,which may be regared as a conventional therapy.