Epidermal cytoplasmic antibodies |
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Authors: | Corrado Betterle Andrea Peserico Giorgio Bersani Franco Rigon Gianfranco Del Prete |
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Institution: | (1) Istituto di Semeiotica Medica, dell’Università degli Studi di Padova, Via Ospedale Civile 105, 35100 Padova, Italia;(2) Clinica Dermatologica, Università degli Studi di Padova, Italia;(3) Clinica Pediatrica, Università degli Studi di Padova, Italia |
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Abstract: | Summary Antibodies to epidermal cytoplasmic antigens were detected by the indirect immunofluorescence (IF) technique in 36% of 100
adult healthy subjects and in 17.6% of 17 normal newborn infants. This type of autoantibody occurred in 33% of 100 cases with
vitiligo, in 32.5% of 40 cases with psoriasis, in 55.3% of patients with malignant tumours and in 72.7% of subjects with malignant
melanoma. The frequency of the autoimmune reactions was statistically significant only in patients with malignant neoplasms.
In the majority of positive cases the IF pattern involved the upper layers of the epidermal cells (U-CYT). The basal layers
was generally negative. Only a few cases showed a pattern involving both the upper and the basal layers (G-CYT). However,
a wide variation in staining was noted when sera were tested on different skin specimens or different sections of the same
skin. To identify the nature of the target antigen(s), absorption experiments of sera were attempted with lyophilized and
particulate antigens. Animal and human blood cells and lyophilized homogenates of malignant tumours failed to absorb the autoimmune
activity of positive sera. Only a powder preparation of keratin induced a decrease in antibody titres. It is postulated that
they are the result of an antigenic stimulation by exogenous substances commonly present in the environment.
This study was supported in part by CNR, Rome, grant no. 75.00465.04. |
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Keywords: | Autoimmune reactions Blood cells Epidermal cytoplasmic antibodies Immunofluorescence Skin Tumours |
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